Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Fluorouracil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fluorouracil SCHEMBL3646 | 0.97 | — | — | |
| Fluorouracil SCHEMBL10017187 | 0.97 | — | — | |
| Fluorouracil SCHEMBL249289 | 0.97 | MAPT (1.00) | — | |
| Fluorouracil SCHEMBL7650203 | 0.95 | MAPT (0.95) | — | |
| Fluorouracil SCHEMBL31441196 | 0.95 | MAPT (0.95) | — | |
| Fluorouracil SCHEMBL28803776 | 0.95 | MAPT (0.95) | — | |
| Fluorouracil SCHEMBL15284932 | 0.95 | MAPT (0.95) | — | |
| Fluorouracil SCHEMBL11327829 | 0.95 | MAPT (0.95) | — | |
| Fluorouracil SCHEMBL21880166 | 0.95 | MAPT (0.95) | — | |
| Fluorouracil SCHEMBL21527805 | 0.95 | MAPT (0.95) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105267143-A | Injection solvent and preparation method and application thereof | SHANGHAI JINWEIZI BIOTECHNOLOGY CO LTD | 2016-01-27 | — | — | CN | disclosed |