Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.50 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1156175 | 0.81 | ALDH1A1 (0.56) | ALDH1A1HSD17B10TDP1DYRK1ARIPK1 | |
| SCHEMBL17691852 | 0.81 | DYRK1A (0.55) | ALDH1A1HSD17B10CYP1B1HIF1ACYP3A4 | |
| SCHEMBL10461143 | 0.81 | ALDH1A1 (0.41) | ALDH1A1HSD17B10CYP1B1HIF1ACYP3A4 | |
| SCHEMBL17691909 | 0.80 | DYRK1A (0.54) | ALDH1A1HSD17B10CYP1B1HIF1ACYP3A4 | |
| SCHEMBL17229095 | 0.80 | DYRK1A (0.57) | ALDH1A1HSD17B10CYP1B1HIF1ACYP3A4 | |
| SCHEMBL17691933 | 0.79 | DYRK1A (0.56) | ALDH1A1HSD17B10CYP1B1HIF1ACYP3A4 | |
| SCHEMBL4137599 | 0.78 | ALDH1A1 (0.52) | ALDH1A1HSD17B10TDP1HPGDDYRK1A | |
| SCHEMBL17691887 | 0.77 | DYRK1A (0.51) | ALDH1A1HSD17B10CYP3A4TDP1DYRK1A | |
| SCHEMBL17691911 | 0.75 | DYRK1A (0.46) | ALDH1A1HSD17B10DYRK1ARIPK1TGFBR1 | |
| SCHEMBL6032431 | 0.74 | ALDH1A1 (0.43) | ALDH1A1HSD17B10HPGDEGFRNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108892637-A | SHIP1 regulator and relative method | 阿奎诺克斯药物（加拿大）公司 | 2018-11-27 | — | — | CN | disclosed |
| CN-105164108-B | SHIP1 modulators and methods related thereto | 阿奎诺克斯药物（加拿大）公司 | 2018-07-17 | — | — | CN | disclosed |
| CN-107573926-A | A kind of double luminous organic fluorescence temperature sensing films and preparation method | 南京邮电大学 | 2018-01-12 | — | — | CN | disclosed |
| CN-105164108-A | SHIP1 modulators and methods related thereto | AQUINOX PHARMACEUTICALS INC | 2015-12-16 | — | — | CN | disclosed |