SCHEMBL28044396

SCHEMBL28044396

O=C(O)C(CC(F)(F)Cc1ccccc1)NC(c1ccc(F)cc1)C(F)(F)F

nearest known ligand 0.48

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
CTSL P07711 10/20 0.46
CTSS P25774 6/20 0.44
CTSB P07858 6/20 0.44
CTSK P43235 2/20 0.44
ALDH1A1 P00352 1/20 0.43
CNR2 P34972 1/20 0.42
CTSF Q9UBX1 2/20 0.42
ACE P12821 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1199773 1.00 CTSL (0.46) CTSLCTSSCTSBCTSKALDH1A1
SCHEMBL1198908 1.00 CTSL (0.46) CTSLCTSSCTSBCTSKALDH1A1
SCHEMBL13585252 0.82 CTSL (0.57) CTSLCTSSCTSBCTSK
SCHEMBL13585251 0.82 CTSL (0.57) CTSLCTSSCTSBCTSK
SCHEMBL12876985 0.81 CTSS (0.46) CTSLCTSSCTSBCTSKACE
SCHEMBL13584819 0.81 CTSS (0.46) CTSLCTSSCTSBCTSKACE
SCHEMBL13584817 0.81 CTSS (0.46) CTSLCTSSCTSBCTSKACE
SCHEMBL1200231 0.80 CTSL (0.69) CTSLCTSSCTSBCTSK
SCHEMBL2191267 0.80 CTSL (0.69) CTSLCTSSCTSBCTSK
SCHEMBL13624177 0.78 CTSL (0.53) CTSLCTSSCTSBCTSKCTSF

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102014635-B Difluoro-containing compounds as cysteine protease inhibitors VIROBAY, INC. (US) 2015-12-16 CN disclosed