Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | RORC | P51449 | 1/20 | 0.46 |
| ▸ | BTK | Q06187 | 3/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | LIPE | Q05469 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1808601 | 0.85 | USP30 (0.46) | MAPK1RORCBTKUSP30GPR119 | |
| SCHEMBL1804183 | 0.85 | USP30 (0.46) | MAPK1RORCBTKUSP30GPR119 | |
| SCHEMBL1804180 | 0.85 | USP30 (0.46) | MAPK1RORCBTKUSP30GPR119 | |
| SCHEMBL19818347 | 0.84 | USP30 (0.47) | MAPK1RORCBTKUSP30GPR119 | |
| SCHEMBL4245207 | 0.82 | USP30 (0.41) | MAPK1RORCBTKUSP30GPR119 | |
| SCHEMBL7710704 | 0.82 | GPR119 (0.56) | MAPK1GPR119NAMPTKDM4E | |
| SCHEMBL4246712 | 0.81 | PDE4B (0.45) | RORCBTKUSP30LIPEKDM4E | |
| SCHEMBL31503219 | 0.80 | RORC (0.41) | MAPK1RORCBTKUSP30LIPE | |
| SCHEMBL2355843 | 0.78 | NR1H2 (0.49) | RORCBTKUSP30GPR119NR1H2 | |
| SCHEMBL19272699 | 0.78 | NR1H2 (0.49) | RORCBTKUSP30GPR119NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025040569-A1 | 1,3-DIHYDRO-2H-PYRROLO[3,4-C]QUINOLINE DERIVATIVES AS CGAS INHIBITORS FOR THE TREATMENT OF INFLAMMATORY AND/OR AUTOIMMUNE DISEASES | KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2025-02-27 | — | — | WO | claimed |
| WO-2025040569-A1 | 1,3-DIHYDRO-2H-PYRROLO[3,4-C]QUINOLINE DERIVATIVES AS CGAS INHIBITORS FOR THE TREATMENT OF INFLAMMATORY AND/OR AUTOIMMUNE DISEASES | KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2025-02-27 | — | — | WO | disclosed |