Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.66 |
| ▸ | LMNA | P02545 | 4/20 | 0.66 |
| ▸ | USP2 | O75604 | 2/20 | 0.66 |
| ▸ | MAPT | P10636 | 1/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.66 |
| ▸ | POLB | P06746 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | DRD2 | P14416 | 1/20 | 0.58 |
| ▸ | HTR2A | P28223 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CA7 | P43166 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15546947 | 0.91 | POLB (0.64) | TSHRLMNAUSP2MAPTMAPK1 | |
| SCHEMBL1920680 | 0.87 | ALDH1A1 (0.49) | TSHRLMNAUSP2MAPTMAPK1 | |
| SCHEMBL8595777 | 0.84 | POLB (0.87) | TSHRLMNAUSP2MAPTMAPK1 | |
| SCHEMBL5546278 | 0.83 | POLB (0.69) | TSHRLMNAUSP2MAPTMAPK1 | |
| SCHEMBL7124360 | 0.83 | MEN1 (0.69) | TSHRLMNAUSP2MAPTMAPK1 | |
| SCHEMBL1921183 | 0.81 | HPGD (0.55) | LMNAUSP2MAPK1POLBMEN1 | |
| SCHEMBL1298628 | 0.81 | HPGD (0.59) | LMNAUSP2MAPK1POLBMEN1 | |
| SCHEMBL10721777 | 0.81 | MEN1 (0.87) | TSHRLMNAUSP2MAPTMAPK1 | |
| SCHEMBL28648111 | 0.81 | KDM4E (0.72) | TSHRLMNAUSP2MAPTMAPK1 | |
| SCHEMBL7002476 | 0.80 | HSP90AA1 (0.44) | USP2KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105073745-A | Glucosylceramide synthase inhibitors | GENZYME CORP | 2015-11-18 | — | — | CN | disclosed |