Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1920680 | 0.92 | ALDH1A1 (0.49) | BLMALDH1A1TP53HPGDUSP2 | |
| SCHEMBL1298702 | 0.87 | POLB (0.54) | HPGDKMT2AHRH3 | |
| SCHEMBL1921183 | 0.85 | HPGD (0.55) | ALDH1A1HPGDUSP2KMT2A | |
| SCHEMBL1298628 | 0.85 | HPGD (0.59) | ALDH1A1HPGDUSP2KMT2A | |
| SCHEMBL1298971 | 0.83 | HPGD (0.62) | ALDH1A1HPGDUSP2KMT2A | |
| SCHEMBL4042348 | 0.82 | KMT2A (0.57) | HPGDKMT2AHRH3 | |
| SCHEMBL28206731 | 0.81 | KDM4E (0.49) | BLMALDH1A1KDM4EKMT2A | |
| SCHEMBL2321965 | 0.81 | ACHE (0.67) | ALDH1A1TP53HPGDACHEKDM4E | |
| SCHEMBL162992 | 0.81 | HPGD (0.58) | HPGDKDM4EKMT2A | |
| SCHEMBL17766536 | 0.81 | SIGMAR1 (0.65) | HPGDHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347971-A1 | THIAZOLYL INHIBITORS OF TEC FAMILY TYROSINE KINASES | Bristol-Myers Squibb Company (US) | 2003-10-01 | — | — | EP | disclosed |
| WO-2002050071-A1 | THIAZOLYL INHIBITORS OF TEC FAMILY TYROSINE KINASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-06-27 | — | — | WO | disclosed |