Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 9/20 | 0.71 |
| ▸ | MEN1 | O00255 | 8/20 | 0.71 |
| ▸ | NPC1 | O15118 | 5/20 | 0.71 |
| ▸ | RAB9A | P51151 | 2/20 | 0.71 |
| ▸ | ATM | Q13315 | 1/20 | 0.71 |
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | PRNP | P04156 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4902003 | 0.85 | MEN1 (0.69) | KMT2AMEN1NPC1RAB9AATM | |
| SCHEMBL28135243 | 0.81 | KMT2A (0.72) | KMT2AMEN1NPC1RAB9AATM | |
| SCHEMBL28135323 | 0.81 | KMT2A (0.72) | KMT2AMEN1NPC1RAB9AATM | |
| Hydrazine SCHEMBL3298022 | 0.78 | KMT2A (0.68) | KMT2AMEN1NPC1RAB9AATM | |
| SCHEMBL4903205 | 0.76 | KMO (0.57) | KMT2AMEN1NPC1RAB9AATM | |
| SCHEMBL28251670 | 0.75 | MEN1 (0.64) | KMT2AMEN1NPC1RAB9AATM | |
| SCHEMBL28251671 | 0.75 | NPC1 (0.74) | KMT2AMEN1NPC1RAB9AATM | |
| SCHEMBL28988552 | 0.75 | XDH (0.56) | KMT2AMEN1NPC1RAB9AATM | |
| SCHEMBL2349591 | 0.73 | MEN1 (0.66) | KMT2AMEN1NPC1RAB9AATM | |
| SCHEMBL3125871 | 0.72 | MAPT (0.51) | KMT2AMEN1NPC1RAB9AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105073745-A | Glucosylceramide synthase inhibitors | GENZYME CORP | 2015-11-18 | — | — | CN | disclosed |