Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Tetrahydrofuran. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetrahydrofuran SCHEMBL3367682 | 0.91 | ALDH1A1 (0.40) | ALDH1A1GLASMN1; SMN2 | |
| Tetrahydrofuran SCHEMBL28342643 | 0.89 | ALDH1A1 (0.38) | ALDH1A1SMN1; SMN2 | |
| Tetrahydrofuran SCHEMBL7279007 | 0.89 | ALDH1A1 (0.42) | ALDH1A1GLASMN1; SMN2 | |
| Tetrahydrofuran SCHEMBL28993307 | 0.87 | ALDH1A1 (0.36) | ALDH1A1SMN1; SMN2 | |
| Tetrahydrofuran SCHEMBL4406239 | 0.87 | ALDH1A1 (0.44) | ALDH1A1 | |
| Tetrahydrofuran SCHEMBL7645655 | 0.82 | ALDH1A1 (0.50) | ALDH1A1GLASMN1; SMN2 | |
| Tetrahydrofuran SCHEMBL1056026 | 0.82 | ALDH1A1 (0.50) | ALDH1A1GLASMN1; SMN2 | |
| Tetrahydrofuran SCHEMBL11401799 | 0.82 | ALDH1A1 (0.50) | ALDH1A1GLASMN1; SMN2 | |
| Acetic Acid SCHEMBL6619942 | 0.82 | FFAR3 (0.44) | ALDH1A1 | |
| Tetrahydrofuran SCHEMBL28312571 | 0.81 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105193826-B | The preparation method of vitamine D3 premix and its vitamine D3 premix obtained | 黄玉萍 | 2019-01-08 | — | — | CN | disclosed |
| CN-105193826-A | Preparation method of vitamin D3 premix and vitamin D3 premix prepared through preparation method | HUANG YUPING | 2015-12-30 | — | — | CN | disclosed |