Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Tetrahydrofuran. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetrahydrofuran SCHEMBL28342643 | 0.98 | ALDH1A1 (0.38) | ALDH1A1SMN1; SMN2FFAR3LCKFYN | |
| Tetrahydrofuran SCHEMBL3367682 | 0.95 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2FFAR3LCKFYN | |
| Dioxane SCHEMBL9344490 | 0.88 | SMN1; SMN2 (0.41) | SMN1; SMN2FFAR3LCKFYN | |
| Tetrahydrofuran SCHEMBL9461279 | 0.88 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2FFAR3LCKFYN | |
| Tetrahydrofuran SCHEMBL1686095 | 0.88 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2FFAR3LCKFYN | |
| Tetrahydrofuran SCHEMBL28044988 | 0.87 | ALDH1A1 (0.33) | ALDH1A1SMN1; SMN2 | |
| Tetrahydrofuran SCHEMBL8440428 | 0.85 | ALDH1A1 (0.50) | ALDH1A1 | |
| Tetrahydrofuran SCHEMBL1056026 | 0.85 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2FFAR3LCKFYN | |
| Tetrahydrofuran SCHEMBL7645655 | 0.85 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2FFAR3LCKFYN | |
| Tetrahydrofuran SCHEMBL7457134 | 0.85 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2FFAR3LCKFYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116026966-A | Detection method for determining related substances of oxaagole sodium by HPLC | 哈药集团技术中心 | 2023-04-28 | — | — | CN | claimed |
| CN-116026966-A | Detection method for determining related substances of oxaagole sodium by HPLC | 哈药集团技术中心 | 2023-04-28 | — | — | CN | disclosed |