Sugi Predict

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SCHEMBL2804528

SCHEMBL2804528

CN(C)C(=O)C(N)Cc1cccc(Oc2cccc(C#N)c2)c1

nearest known ligand 0.43

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ DPP7 Q9UHL4 3/20 0.43
▸ DPP4 P27487 2/20 0.43
▸ FAP Q12884 1/20 0.43
▸ DPP8 Q6V1X1 1/20 0.43
▸ DPP9 Q86TI2 1/20 0.43
▸ MAOB P27338 1/20 0.43
▸ SMN1; SMN2 Q16637 1/20 0.41
▸ ALOX5 P09917 2/20 0.41
▸ SCN9A Q15858 1/20 0.40
▸ FOLH1 Q04609 1/20 0.40
▸ PRCP P42785 1/20 0.39
▸ GPR34 Q9UPC5 1/20 0.39
▸ ACHE P22303 3/20 0.39
▸ FFAR1 O14842 1/20 0.39
▸ MGLL Q99685 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL2804437 0.99 DPP7 (0.43) DPP7DPP4FAPDPP8DPP9
SCHEMBL2806130 0.82 GPR34 (0.48) MAOBSMN1; SMN2GPR34
SCHEMBL2805855 0.78 CTSS (0.51) GPR34
SCHEMBL2804402 0.78 SLC7A5 (0.53) SMN1; SMN2FFAR1
SCHEMBL5125574 0.77 HDAC8 (0.49) FFAR1
Hydrochloric Acid SCHEMBL2803610 0.77 SLC7A5 (0.52) SMN1; SMN2FFAR1
SCHEMBL23270320 0.76 DPP4 (0.48) DPP7DPP4FAPDPP8DPP9
SCHEMBL21144845 0.76 DPP4 (0.48) DPP7DPP4FAPDPP8DPP9
SCHEMBL21144842 0.76 DPP4 (0.48) DPP7DPP4FAPDPP8DPP9
SCHEMBL14462339 0.76 DPP7 (0.56) DPP7DPP4FAPDPP8DPP9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130296327-A1 SUBSTITUTED HETEROCYLIC COMPOUNDS INCYTE CORPORATION 2013-11-07 — — US disclosed
US-20130296327-A1 SUBSTITUTED HETEROCYLIC COMPOUNDS INCYTE CORPORATION 2013-11-07 — — US disclosed
US-20130296327-A1 SUBSTITUTED HETEROCYLIC COMPOUNDS INCYTE CORPORATION 2013-11-07 — — US disclosed
US-8481732-B2 Substituted heterocyclic compounds INCYTE CORPORATION (US) 2013-07-09 — — US disclosed
US-8481732-B2 Substituted heterocyclic compounds INCYTE CORPORATION (US) 2013-07-09 — — US disclosed
US-8481732-B2 Substituted heterocyclic compounds INCYTE CORPORATION (US) 2013-07-09 — — US disclosed
US-20100240671-A1 SUBSTITUTED HETEROCYCLIC COMPOUNDS INCYTE CORPORATION (US) 2010-09-23 — — US disclosed
US-20100240671-A1 SUBSTITUTED HETEROCYCLIC COMPOUNDS INCYTE CORPORATION (US) 2010-09-23 — — US disclosed
US-20100240671-A1 SUBSTITUTED HETEROCYCLIC COMPOUNDS INCYTE CORPORATION (US) 2010-09-23 — — US disclosed
WO-2010108059-A1 SUBSTITUTED PYRIMIDINE DERIVATIVES AS ANTAGONISTS OF THE HISTAMINE H4 RECEPTOR INCYTE CORPORATION (US) 2010-09-23 — — WO disclosed
WO-2010108059-A1 SUBSTITUTED PYRIMIDINE DERIVATIVES AS ANTAGONISTS OF THE HISTAMINE H4 RECEPTOR INCYTE CORPORATION (US) 2010-09-23 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130296327-A1 SUBSTITUTED HETEROCYLIC COMPOUNDS HRH4, HRH2, HRH1 DPP7 4576/4885DPP4 3575/4885FAP 2668/4885
US-20100240671-A1 SUBSTITUTED HETEROCYCLIC COMPOUNDS HRH4, HRH2, HRH1 DPP7 4202/4885DPP4 1487/4885FAP 2890/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.