Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL63735 | 0.96 | TSHR (0.33) | TSHRALDH1A1TP53CYP3A4MAPK1 | |
| Acrylic Acid SCHEMBL28501960 | 0.95 | LMNA (0.33) | TSHRALDH1A1TP53CYP3A4MAPK1 | |
| SCHEMBL28372269 | 0.93 | TSHR (0.32) | TSHRALDH1A1TP53CYP3A4MAPK1 | |
| Methane SCHEMBL28321630 | 0.93 | TSHR (0.32) | TSHRALDH1A1TP53CYP3A4MAPK1 | |
| SCHEMBL28958929 | 0.90 | TSHR (0.30) | TSHR | |
| SCHEMBL31285604 | 0.87 | — | — | |
| SCHEMBL31155812 | 0.85 | TSHR (0.30) | TSHR | |
| Acrylic Acid SCHEMBL28725990 | 0.84 | TSHR (0.50) | TSHRALDH1A1TP53CYP3A4MAPK1 | |
| SCHEMBL29006648 | 0.81 | TSHR (0.58) | TSHRALDH1A1TP53CYP3A4MAPK1 | |
| SCHEMBL3132072 | 0.81 | ALDH1A1 (0.35) | TSHRALDH1A1TP53CYP3A4MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105131197-A | Preparation method of polycarbonate photodiffusion material | ZHEJIANG QUZHOU WANNENGDA TECHNOLOGY CO LTD | 2015-12-09 | — | — | CN | disclosed |