SCHEMBL280454

SCHEMBL280454

c1ccc(-c2nccn2-c2ccc3oc4ccc(-c5ccc6oc7ccc(-n8ccnc8-c8ccccc8)cc7c6c5)cc4c3c2)cc1

nearest known ligand 0.49

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
MAPK9 P45984 1/20 0.49
MAPK10 P53779 1/20 0.49
KDR P35968 11/20 0.45
PLA2G2A P14555 1/20 0.38
PLA2G4A P47712 1/20 0.38
MAOA P21397 1/20 0.38
MAOB P27338 1/20 0.38
MAPKAPK2 P49137 2/20 0.38
P2RX4 Q99571 1/20 0.38
FLT1 P17948 2/20 0.37
FLT4 P35916 2/20 0.37
GAA P10253 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL280119 0.97 MAPK9 (0.47) MAPK9MAPK10KDRPLA2G2APLA2G4A
SCHEMBL10035818 0.96 MAPK9 (0.52) MAPK9MAPK10KDRMAOAMAOB
SCHEMBL10035820 0.92 MAPK9 (0.49) MAPK9MAPK10KDRMAOAMAOB
SCHEMBL280277 0.87 MAPK9 (0.45) MAPK9MAPK10KDRMAOAMAOB
SCHEMBL10035826 0.87 KDR (0.40) MAPK9MAPK10KDRPLA2G2APLA2G4A
SCHEMBL280259 0.85 MAPK9 (0.45) MAPK9MAPK10KDRMAOAMAOB
SCHEMBL14867937 0.85 MAPK9 (0.43) MAPK9MAPK10KDRMAOAMAOB
SCHEMBL20732577 0.84 MAPK9 (0.49) MAPK9MAPK10KDRMAOAMAOB
SCHEMBL20097813 0.83 MAPK9 (0.42) MAPK9MAPK10KDRMAOAMAOB
SCHEMBL13450212 0.83 MAPT (0.46) MAPK9MAPK10KDRMAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9067919-B2 Use of dibenzofurans and dibenzothiophenes substituted by nitrogen-bonded five-membered heterocyclic rings in organic electronics BASF SE (DE) 2015-06-30 US disclosed
US-9067919-B2 Use of dibenzofurans and dibenzothiophenes substituted by nitrogen-bonded five-membered heterocyclic rings in organic electronics BASF SE (DE) 2015-06-30 US disclosed
WO-2012004765-A2 USE OF DIBENZOFURANS AND DIBENZOTHIOPHENES SUBSTITUTED BY NITROGEN-BONDED FIVE-MEMBERED HETEROCYCLIC RINGS IN ORGANIC ELECTRONICS BASF SE (DE) 2012-01-12 WO disclosed
US-20120007063-A1 USE OF DIBENZOFURANS AND DIBENZOTHIOPHENES SUBSTITUTED BY NITROGEN-BONDED FIVE-MEMBERED HETEROCYCLIC RINGS IN ORGANIC ELECTRONICS BASF SE (DE) 2012-01-12 US disclosed
US-20120007063-A1 USE OF DIBENZOFURANS AND DIBENZOTHIOPHENES SUBSTITUTED BY NITROGEN-BONDED FIVE-MEMBERED HETEROCYCLIC RINGS IN ORGANIC ELECTRONICS BASF SE (DE) 2012-01-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120007063-A1 USE OF DIBENZOFURANS AND DIBENZOTHIOPHENES SUBSTITUTED BY NITROGEN-BONDED FIVE-MEMBERED HETEROCYCLIC RINGS IN ORGANIC ELECTRONICS DDT, DBF4, POU5F1 MAPK9 3614/4885MAPK10 3165/4885KDR 1620/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.