POU5F1

POU domain, class 5, transcription factor 1 · Q01860 · POU5F1 on Sugi Atlas →

786 patent compounds predicted against POU5F1, 309 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Famotidine (SCHEMBL973)	1.00	2/20
Famotidine (SCHEMBL39237)	1.00	2/20
Famotidine (SCHEMBL458654)	1.00	2/20
Famotidine (SCHEMBL29384901)	1.00	2/20
Famotidine (SCHEMBL1863201)	0.98	2/20
Famotidine (SCHEMBL22127098)	0.98	2/20
Famotidine (SCHEMBL28032679)	0.98	2/20
Famotidine (SCHEMBL1863206)	0.95	2/20
Famotidine (SCHEMBL7119657)	0.95	2/20
Famotidine (SCHEMBL9817308)	0.95	2/20
Famotidine (SCHEMBL28528271)	0.95	2/20
Famotidine (SCHEMBL7121892)	0.93	2/20
Famotidine (SCHEMBL28102513)	0.91	2/20
Famotidine (SCHEMBL2321295)	0.88	2/20
Famotidine (SCHEMBL18335717)	0.88	2/20
SCHEMBL23804922	0.87	2/20
SCHEMBL23804924	0.87	2/20
Famotidine (SCHEMBL18335722)	0.86	2/20
Famotidine (SCHEMBL27832811)	0.86	2/20
Famotidine (SCHEMBL27812646)	0.84	2/20

Clinical trials — most relevant to POU5F1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Mechanisms of Lipodystrophy in HIV-Infected Pateints	PHASE4	COMPLETED
Applying Proton Pump Inhibitor to Prevent and Treat Acute Fluctuating Hearing Loss in Patients With SLC26A4 Mutation	PHASE2/PHASE3	UNKNOWN
Evaluation of a Cancer Lysate Vaccine and Montanide (Registered Trademark) ISA-51 VG With or Without the IL-15 Super-Agonist N-803 as Adjuvant Therapy for PD-L1 Negative Non-Small Cell Lung Cancer	PHASE1/PHASE2	SUSPENDED
Treatment Duration Increment and Pharmacodynamic Study of CX-4945 in Patients With Basal Cell Carcinoma (BCC)	PHASE1	COMPLETED
Can Gluten-free Diet Prevent the Destruction of Beta-cells During Remission?	EARLY_PHASE1	UNKNOWN
Epigenomic Profiling of Circulating Cell-Free DNA (cfDNA) to Characterize the Dynamic Evolution of Molecular Subtypes in Extensive-Stage Small Cell Lung Cancer During First-Line Chemoimmunotherapy	nan	NOT_YET_RECRUITING
Patient Specific Induced Pluripotency Stem Cells (PSiPS)	nan	COMPLETED
Development of IPS from Donated Somatic Cells of Patients with Neurological Diseases	nan	RECRUITING
The Role of TBX3 in Human ES Cell Differentiation	nan	WITHDRAWN
Transcription Factor Runx2 in Necrotic Femoral Head Tissue	nan	COMPLETED
Human iPSC for Repair of Vasodegenerative Vessels in Diabetic Retinopathy	nan	RECRUITING
Production of Stem Cells for the Generation of Pancreatic Cells	nan	RECRUITING
Derivation of Induced Pluripotent Stem Cells From an Existing Collection of Human Somatic Cells	nan	RECRUITING
Autophagy in Systemic Lupus Erythematosus	nan	UNKNOWN
Transcriptomic Responses for the Identification of Pathogens	nan	RECRUITING
EKLF Gene Expression in β-thalassemia	nan	NOT_YET_RECRUITING
Identifying Genes and Mutations Underlying Retinitis Pigmentosa and Allied Diseases	nan	UNKNOWN
Use of Existing Fibroblast Cells to Convert to Induced Pluripotent Stem Cells	nan	RECRUITING
Detection of IKZF1 Deletion Mutation in Patients With Acute Lymphoblastic Leukemia and Its Impact in Therapy	nan	UNKNOWN
Exome Analysis in Hearing Impaired Patients	nan	UNKNOWN
Study of Neurodegenerative Diseases Induced Stem Cells in Patients and Healthy Family Controls.	nan	UNKNOWN
EPIgenetics and in Vivo Resistance of Chronic Myeloid Leukemia Stem Cells to Tyrosine Kinase Inhibitors	nan	UNKNOWN
Whole Transcriptome Profiling and Metabolic Phenotyping in Children With ROHHAD Syndrome	nan	RECRUITING
RORC Genetic Polymorphism of Rheumatoid Arthritis	nan	COMPLETED
MR Elastography in Intracranial Lesions: Feasibility & Accuracy	nan	ACTIVE_NOT_RECRUITING
Diagnosis of RSTS: Identification of the Acetylation Profiles as Epigenetic Markers for Assessing Causality of CREBBP and EP300 Variants.	nan	UNKNOWN
Azoospermia Patients	nan	RECRUITING
BATokines as Biomarkers of Brown Fat in Humans	nan	ACTIVE_NOT_RECRUITING
Developing Derived Induced Pluripotent Stem Cells as a Model to Understand Imprinted Disorders	nan	ENROLLING_BY_INVITATION
Effect of Post Covid-19 Hypoxia on Placenta of Normal Pregnant Women: A Possible Role of Hypoxia Inducible Factor-1α.	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a POU5F1 binder may also engage these)

Protein	Name	Similarity
Q7YR49	—	1.000	Q7YR49 →
Q9TSV5	—	1.000	Q9TSV5 →
P20263	—	1.000	P20263 →
Q5TM49	—	1.000	Q5TM49 →
Q06416	—	1.000	Q06416 →
B3DM23	—	1.000	B3DM23 →
O97552	—	1.000	O97552 →
A7Y7W2	—	0.997	A7Y7W2 →
Q6PZD9	—	0.996	Q6PZD9 →
P18864	—	0.995	P18864 →
A2T764	—	0.995	A2T764 →
P55318	—	0.995	P55318 →
NR4A1	Nuclear receptor subfamily 4immunitygroup A member 1	0.995	landscape →
A2D5I1	—	0.994	A2D5I1 →
A2T733	—	0.994	A2T733 →
Q8NFW5	—	0.994	Q8NFW5 →
A6NNA5	—	0.994	A6NNA5 →
MIDEAS	Mitotic deacetylase-associated SANT domain protein	0.994	landscape →
P81062	—	0.994	P81062 →
P22361	—	0.993	P22361 →
Q1KKW8	—	0.993	Q1KKW8 →
Q00417	—	0.993	Q00417 →
P43697	—	0.993	P43697 →
Q08478	—	0.993	Q08478 →
Q96NZ1	—	0.993	Q96NZ1 →
P52951	—	0.993	P52951 →
Q2MJB4	—	0.993	Q2MJB4 →
Q5XKR4	—	0.993	Q5XKR4 →
Q9I8H0	—	0.993	Q9I8H0 →
PAX3	Paired box protein Pax-3 (HuP2)	0.993	landscape →