Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 3/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.39 |
| ▸ | NAMPT | P43490 | 3/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HTR5A | P47898 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15971513 | 0.84 | NAMPT (0.42) | PDCD1CD274NAMPTCHEK1 | |
| SCHEMBL15986863 | 0.78 | L3MBTL1 (0.44) | PDCD1CD274NAMPTALDH1A1L3MBTL1 | |
| SCHEMBL112780 | 0.74 | L3MBTL1 (0.43) | ALDH1A1L3MBTL1KDM4ESMN1; SMN2BRAF | |
| SCHEMBL13280071 | 0.74 | L3MBTL1 (0.43) | PDCD1CD274CHEK1ALDH1A1L3MBTL1 | |
| SCHEMBL27961472 | 0.73 | PDCD1 (0.42) | PDCD1CD274NAMPTALDH1A1KDM4E | |
| SCHEMBL17161607 | 0.73 | SCN10A (0.43) | NAMPTALDH1A1L3MBTL1KDM4ECYP2C9 | |
| SCHEMBL13466389 | 0.71 | L3MBTL1 (0.59) | CD274CHEK1L3MBTL1TBK1BRAF | |
| SCHEMBL25328772 | 0.71 | CNR1 (0.37) | NAMPTALDH1A1L3MBTL1KDM4ECYP2C9 | |
| SCHEMBL30635459 | 0.71 | L3MBTL1 (0.49) | PDCD1CD274ALDH1A1L3MBTL1CYP2C9 | |
| SCHEMBL25329428 | 0.71 | NPC1 (0.42) | NAMPTALDH1A1KDM4ECYP2C9POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105189480-A | Pyrimidine compounds useful in the treatment of disorders mediated by the IKK and/or TBK-1 mechanism | DOMAINEX LTD | 2015-12-23 | — | — | CN | disclosed |