Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.44 |
| ▸ | KCNJ5 | P48544 | 3/20 | 0.42 |
| ▸ | KCNJ3 | P48549 | 3/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | SHBG | P04278 | 1/20 | 0.41 |
| ▸ | APAF1 | O14727 | 1/20 | 0.41 |
| ▸ | TDP2 | O95551 | 1/20 | 0.41 |
| ▸ | NSD2 | O96028 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.41 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.41 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7644730 | 0.88 | NPC1 (0.49) | NPC1RAB9ACTBP2KCNJ5KCNJ3 | |
| SCHEMBL28909042 | 0.83 | NPC1 (0.47) | NPC1RAB9ACTBP2KCNJ5KCNJ3 | |
| SCHEMBL1137595 | 0.81 | RECQL (0.47) | KMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL6194349 | 0.78 | CTBP2 (0.58) | NPC1RAB9ACTBP2KCNJ5KCNJ3 | |
| SCHEMBL31365969 | 0.78 | CTBP2 (0.58) | NPC1RAB9ACTBP2KCNJ5KCNJ3 | |
| SCHEMBL8209138 | 0.78 | CTBP2 (0.54) | NPC1RAB9ACTBP2KCNJ5KCNJ3 | |
| SCHEMBL872658 | 0.78 | NPC1 (0.52) | NPC1RAB9ACTBP2KCNJ5KCNJ3 | |
| SCHEMBL29498164 | 0.78 | NPC1 (0.52) | NPC1RAB9ACTBP2KCNJ5KCNJ3 | |
| SCHEMBL10955526 | 0.76 | ALDH1A1 (0.48) | NPC1RAB9ALMNAALDH1A1MAPT | |
| SCHEMBL7634176 | 0.76 | CES2 (0.52) | NPC1RAB9AKMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105121432-A | Heterocyclic amides as kinase inhibitors | GLAXOSMITHKLINE IP DEV LTD | 2015-12-02 | — | — | CN | disclosed |