Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR34 | Q9UPC5 | 9/20 | 0.74 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.70 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.70 |
| ▸ | PPARG | P37231 | 4/20 | 0.68 |
| ▸ | MME | P08473 | 1/20 | 0.64 |
| ▸ | ACE | P12821 | 1/20 | 0.64 |
| ▸ | CPA1 | P15085 | 1/20 | 0.64 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.64 |
| ▸ | GPR132 | Q9UNW8 | 2/20 | 0.64 |
| ▸ | YAP1 | P46937 | 1/20 | 0.59 |
| ▸ | PPARA | Q07869 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5398899 | 1.00 | GPR34 (0.74) | GPR34ITGB3ITGA2BPPARGMME | |
| SCHEMBL28045699 | 1.00 | GPR34 (0.74) | GPR34ITGB3ITGA2BPPARGMME | |
| SCHEMBL12989411 | 0.91 | GPR34 (0.72) | GPR34ITGB3ITGA2BPPARGMME | |
| SCHEMBL12475389 | 0.91 | GPR34 (0.72) | GPR34ITGB3ITGA2BPPARGMME | |
| SCHEMBL31390144 | 0.90 | GPR34 (0.71) | GPR34ITGB3ITGA2BPPARGMME | |
| SCHEMBL14413890 | 0.90 | GPR34 (0.71) | GPR34ITGB3ITGA2BPPARGMME | |
| SCHEMBL9052952 | 0.87 | PPARG (0.69) | GPR34ITGB3ITGA2BPPARGMME | |
| SCHEMBL4144665 | 0.87 | ITGB3 (0.65) | ITGB3ITGA2BMMEACECPA1 | |
| SCHEMBL10504767 | 0.87 | ITGB3 (0.65) | ITGB3ITGA2BMMEACECPA1 | |
| SCHEMBL4144668 | 0.87 | ITGB3 (0.65) | ITGB3ITGA2BMMEACECPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105175418-B | Pentacyclic indole quinolizine for inhibiting autophagy of cells, synthesis, antitumor activity and application thereof | 首都医科大学 | 2020-01-14 | — | — | CN | disclosed |
| CN-105175418-A | Pentacyclic indole quinolizine inhibiting cell autophagy, synthesis, antitumor activity and application thereof | UNIV CAPITAL MEDICAL SCIENCES | 2015-12-23 | — | — | CN | disclosed |