Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 3/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.37 |
| ▸ | TUBB | P07437 | 1/20 | 0.37 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.37 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.37 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.37 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.37 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.37 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.37 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.37 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.37 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.37 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.37 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.37 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.37 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3580870 | 0.83 | POLB (0.44) | POLBCNR2NR4A2LMNAKMT2A | |
| SCHEMBL27872763 | 0.82 | POLB (0.41) | POLBCNR2NR4A2ABCG2LMNA | |
| SCHEMBL20604979 | 0.79 | NR4A2 (0.59) | NR4A2KMT2AALDH1A1MAPT | |
| SCHEMBL7501630 | 0.79 | KMT2A (0.40) | POLBCNR2NR4A2LMNAKMT2A | |
| SCHEMBL27984454 | 0.77 | POLB (0.38) | POLBNR4A2ABCG2LMNAKMT2A | |
| SCHEMBL1429258 | 0.74 | ALDH1A1 (0.54) | CNR2LMNAKMT2AALDH1A1MAPT | |
| SCHEMBL10349904 | 0.74 | POLB (0.66) | POLBNR4A2ABCG2LMNAKMT2A | |
| SCHEMBL1925007 | 0.74 | CNR2 (0.47) | POLBCNR2LMNAKMT2AMAPT | |
| SCHEMBL27708004 | 0.71 | SLC22A12 (0.45) | CNR2KMT2AALDH1A1MAPTCNR1 | |
| SCHEMBL27716622 | 0.71 | ALDH1A1 (0.50) | POLBCNR2LMNAKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105218565-A | Spiral shell oxindole compounds and the purposes as therapeutical agent thereof | XENON PHARMACEUTICALS INC | 2016-01-06 | — | — | CN | disclosed |
| CN-105175433-A | Spiro-oxindole compounds and their use as therapeutic agents | XENON PHARMACEUTICALS INC | 2015-12-23 | — | — | CN | disclosed |