Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 6/20 | 0.36 |
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2305769 | 0.83 | KMT2A (0.48) | ALDH1A1SMN1; SMN2MAPTTP53OPRM1 | |
| SCHEMBL2306983 | 0.78 | SCN9A (0.39) | ALDH1A1SMN1; SMN2TP53OPRM1OPRD1 | |
| SCHEMBL15315022 | 0.76 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2MAPTOPRM1OPRD1 | |
| SCHEMBL2306628 | 0.76 | ALDH1A1 (0.37) | ALDH1A1SMN1; SMN2MAPTOPRM1OPRD1 | |
| SCHEMBL385967 | 0.75 | MEN1 (0.40) | ALDH1A1SMN1; SMN2MAPTTP53OPRM1 | |
| SCHEMBL2305324 | 0.75 | OPRM1 (0.39) | ALDH1A1SMN1; SMN2OPRM1OPRD1OPRK1 | |
| SCHEMBL281494 | 0.75 | OPRM1 (0.41) | ALDH1A1SMN1; SMN2MAPTTP53OPRM1 | |
| SCHEMBL2305064 | 0.75 | KMT2A (0.42) | ALDH1A1SMN1; SMN2OPRM1OPRD1OPRK1 | |
| SCHEMBL3328359 | 0.74 | SMN1; SMN2 (0.38) | ALDH1A1SMN1; SMN2MAPTTP53OPRM1 | |
| SCHEMBL3327230 | 0.74 | CBX7 (0.37) | ALDH1A1SMN1; SMN2MAPTTSHRSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103664973-B | Spiro-oxindole compounds and their use as therapeutic agents | 泽农医药公司 | 2017-04-19 | — | — | CN | disclosed |
| CN-102256983-B | Spirooxindole compounds and their use as therapeutic agents | 泽农医药公司 | 2017-04-05 | — | — | CN | disclosed |
| CN-105218565-A | Spiral shell oxindole compounds and the purposes as therapeutical agent thereof | XENON PHARMACEUTICALS INC | 2016-01-06 | — | — | CN | disclosed |
| CN-105175433-A | Spiro-oxindole compounds and their use as therapeutic agents | XENON PHARMACEUTICALS INC | 2015-12-23 | — | — | CN | disclosed |