Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 7/20 | 0.50 |
| ▸ | BCL2 | P10415 | 6/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | ACLY | P53396 | 1/20 | 0.38 |
| ▸ | PKLR | P30613 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | S100A4 | P26447 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11072946 | 0.88 | BCL2 (0.67) | MCL1BCL2HSD17B10HPGDMAOA | |
| SCHEMBL27428387 | 0.87 | BCL2 (0.72) | MCL1BCL2TSHRHSD17B10HPGD | |
| SCHEMBL11069824 | 0.86 | HSP90AA1 (0.61) | MCL1BCL2TSHRHSD17B10HPGD | |
| SCHEMBL7980260 | 0.81 | BCL2 (0.70) | MCL1BCL2TSHRHSD17B10HPGD | |
| SCHEMBL4321232 | 0.78 | AHR (0.53) | MCL1BCL2TSHRHSD17B10HPGD | |
| SCHEMBL8821657 | 0.78 | BCL2 (0.74) | MCL1BCL2TSHRHSD17B10HPGD | |
| SCHEMBL11075972 | 0.75 | CYP1A1 (0.45) | MCL1BCL2TSHRHSD17B10HPGD | |
| SCHEMBL20191216 | 0.74 | STAT3 (0.60) | MCL1BCL2HSD17B10HPGDHSP90AA1 | |
| SCHEMBL9731778 | 0.74 | HSD17B10 (0.68) | TSHRHSD17B10HPGDHSP90AA1ADRA1A | |
| SCHEMBL10357236 | 0.73 | HSD17B10 (0.67) | TSHRHSD17B10HPGDHSP90AA1ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103145730-B | Two thieno-fluorenes and derivative and preparation method | EAST CHINA NORMAL UNIVERSITY (CN) | 2016-02-03 | — | — | CN | claimed |
| CN-103145730-B | Two thieno-fluorenes and derivative and preparation method | EAST CHINA NORMAL UNIVERSITY (CN) | 2016-02-03 | — | — | CN | disclosed |
| CN-103145730-B | Two thieno-fluorenes and derivative and preparation method | EAST CHINA NORMAL UNIVERSITY (CN) | 2016-02-03 | — | — | CN | disclosed |