SCHEMBL7980260

SCHEMBL7980260

O=C1c2cc(O)c(O)cc2-c2cc(O)c(O)cc21

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BCL2 P10415 8/20 0.70
MCL1 Q07820 8/20 0.70
MAOA P21397 5/20 0.50
MAOB P27338 3/20 0.50
ESR1 P03372 2/20 0.50
ESR2 Q92731 2/20 0.50
UGT1A1 P22309 1/20 0.50
PKLR P30613 1/20 0.43
HSP90AA1 P07900 1/20 0.41
MAPT P10636 3/20 0.40
ALDH1A1 P00352 2/20 0.40
LMNA P02545 2/20 0.40
ALOX15 P16050 2/20 0.40
TSHR P16473 2/20 0.40
MAPK1 P28482 2/20 0.40
HSD17B10 Q99714 2/20 0.40
TDP1 Q9NUW8 2/20 0.40
TTR P02766 1/20 0.40
HPGD P15428 1/20 0.40
HTT P42858 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8821657 0.97 BCL2 (0.74) BCL2MCL1MAOAMAOBESR1
SCHEMBL26205025 0.85 MCL1 (0.61) BCL2MCL1MAOAMAOBESR1
SCHEMBL7979992 0.84 BCL2 (0.91) BCL2MCL1MAOAMAOBESR1
SCHEMBL31253345 0.83 ESR2 (0.74) BCL2MCL1MAOAMAOBESR1
SCHEMBL18068471 0.82 BCL2 (0.45) BCL2MCL1MAPTALDH1A1LMNA
SCHEMBL26205027 0.81 MCL1 (0.56) BCL2MCL1MAOAMAOBESR1
SCHEMBL23968936 0.81 BCL2 (0.54) BCL2MCL1MAOAMAOBESR1
SCHEMBL25719239 0.81 MAPT (0.56) BCL2MCL1MAOAMAOBESR1
SCHEMBL28046162 0.81 MCL1 (0.50) BCL2MCL1MAOAMAOBESR1
SCHEMBL18130042 0.79 ESR2 (0.86) BCL2MCL1MAOAMAOBESR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6194439-B1 ANTICANCER AGENT PFIZER INC. 2001-02-27 US disclosed
US-5942641-A TREATMENT OF ALZHEIMER'S DISEASE, NERVOUS SYSTEM DISORDERS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1999-08-24 US disclosed
EP-0655992-B1 FLUORENONE DERIVATIVES, PROCESS FOR PREPARING THE SAME AND CENTRAL OR PERIPHERAL NERVE DEGENERATION REPAIR AND PROTECTIVE AGENT OTSUKA PHARMA CO LTD (JP) 1998-11-04 EP disclosed
EP-0791570-A1 Fluorenone derivatives, process for preparing the same and central or peripheral nerve degeneration repair and protective agent OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1997-08-27 EP disclosed
EP-0655992-A1 FLUORENONE DERIVATIVES, PROCESS FOR PREPARING THE SAME AND CENTRAL OR PERIPHERAL NERVE DEGENERATION REPAIR AND PROTECTIVE AGENT OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1995-06-07 EP disclosed
WO-1995000468-A1 FLUORENONE DERIVATIVES, PROCESS FOR PREPARING THE SAME AND CENTRAL OR PERIPHERAL NERVE DEGENERATION REPAIR AND PROTECTIVE AGENT OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1995-01-05 WO disclosed
EP-0586608-A1 TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS PFIZER INC. (US) 1994-03-16 EP disclosed
WO-1992021660-A1 TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS PFIZER, INC. (US) 1992-12-10 WO disclosed