Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | BCL2 | P10415 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.41 |
| ▸ | PDE9A | O76083 | 1/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13858621 | 0.90 | KMT2A (0.52) | KMT2AL3MBTL1NTRK1KDM1AMAOB | |
| SCHEMBL15716485 | 0.90 | KMT2A (0.52) | KMT2AL3MBTL1NTRK1KDM1AMAOB | |
| SCHEMBL16780873 | 0.90 | KMT2A (0.52) | KMT2AL3MBTL1NTRK1KDM1AMAOB | |
| SCHEMBL13858620 | 0.90 | KMT2A (0.52) | KMT2AL3MBTL1NTRK1KDM1AMAOB | |
| SCHEMBL16032636 | 0.85 | SIGMAR1 (0.50) | NTRK1SIGMAR1KDM1AMAOBTP53 | |
| SCHEMBL21775812 | 0.84 | SSTR4 (0.47) | KMT2AL3MBTL1NTRK1KDM1AMAOB | |
| SCHEMBL21775811 | 0.84 | SSTR4 (0.47) | KMT2AL3MBTL1NTRK1KDM1AMAOB | |
| SCHEMBL1986245 | 0.84 | KMT2A (0.48) | KMT2AL3MBTL1SIGMAR1KDM1AMAOB | |
| SCHEMBL2012023 | 0.84 | KMT2A (0.48) | KMT2AL3MBTL1SIGMAR1KDM1AMAOB | |
| SCHEMBL23369466 | 0.82 | NTRK1 (0.49) | KMT2AL3MBTL1NTRK1SIGMAR1KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105209457-A | Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy | ABBVIE DEUTSCHLAND | 2015-12-30 | — | — | CN | disclosed |