SCHEMBL28046445

SCHEMBL28046445

Cc1cc(C)c2cc(C)cc(C)c2c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.50
CYP2A6 P11509 2/20 0.50
MAPT P10636 4/20 0.48
RAPGEF4 Q8WZA2 3/20 0.47
ALDH1A1 P00352 5/20 0.39
KDM4E B2RXH2 3/20 0.39
GAA P10253 2/20 0.39
LMNA P02545 1/20 0.39
TSHR P16473 2/20 0.39
PARP1 P09874 2/20 0.38
TP53 P04637 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
HPGD P15428 1/20 0.36
ALOX15 P16050 1/20 0.36
HSD17B10 Q99714 1/20 0.36
MEN1 O00255 1/20 0.35
MPI P34949 1/20 0.35
KMT2A Q03164 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
PSMB5 P28074 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26437116 0.83 ALDH1A1 (0.52) CYP1A2CYP2A6MAPTRAPGEF4ALDH1A1
SCHEMBL598262 0.81 CYP1A2 (0.65) CYP1A2CYP2A6MAPTRAPGEF4ALDH1A1
SCHEMBL29595379 0.81 CYP1A2 (0.65) CYP1A2CYP2A6MAPTRAPGEF4ALDH1A1
SCHEMBL13701496 0.77 CYP1A2 (0.35) CYP1A2CYP2A6MAPTRAPGEF4GAA
SCHEMBL598994 0.76 CYP1A2 (0.39) CYP1A2CYP2A6MAPTRAPGEF4ALDH1A1
SCHEMBL21836746 0.74 CYP1A2 (0.54) CYP1A2CYP2A6MAPTRAPGEF4ALDH1A1
SCHEMBL1551822 0.72 RAPGEF4 (0.59) CYP1A2CYP2A6MAPTRAPGEF4ALDH1A1
SCHEMBL28951 0.72 RAPGEF4 (0.59) CYP1A2CYP2A6MAPTRAPGEF4ALDH1A1
SCHEMBL317299 0.72 RAPGEF4 (0.50) CYP1A2CYP2A6MAPTRAPGEF4ALDH1A1
SCHEMBL18775169 0.72 SMN1; SMN2 (0.43) CYP1A2CYP2A6MAPTRAPGEF4ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105102523-A Stabilization of polyamides with copper-based metal-organic frameworks BASF SE 2015-11-25 CN disclosed