Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE1 | P42892 | 1/20 | 0.71 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.67 |
| ▸ | LTA4H | P09960 | 1/20 | 0.66 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.66 |
| ▸ | ACE | P12821 | 4/20 | 0.65 |
| ▸ | ITGB2 | P05107 | 3/20 | 0.65 |
| ▸ | ICAM1 | P05362 | 3/20 | 0.65 |
| ▸ | ITGAL | P20701 | 3/20 | 0.65 |
| ▸ | POLB | P06746 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11591677 | 1.00 | ECE1 (0.71) | ECE1ALOX15LTA4HP2RY14ACE | |
| SCHEMBL13278205 | 0.92 | ALOX15 (0.70) | ALOX15P2RY14ACEITGB2ICAM1 | |
| SCHEMBL29987387 | 0.92 | ALOX15 (0.70) | ALOX15P2RY14ACEITGB2ICAM1 | |
| SCHEMBL3728145 | 0.92 | ALOX15 (0.70) | ALOX15P2RY14ACEITGB2ICAM1 | |
| SCHEMBL11863617 | 0.92 | ITGB2 (0.67) | ECE1ALOX15P2RY14ACEITGB2 | |
| SCHEMBL4680711 | 0.90 | ECE1 (0.68) | ECE1LTA4HP2RY14ERAP2 | |
| SCHEMBL503091 | 0.90 | KMT2A (0.68) | ECE1ALOX15LTA4HP2RY14ACE | |
| SCHEMBL30069244 | 0.90 | KMT2A (0.68) | ECE1ALOX15LTA4HP2RY14ACE | |
| SCHEMBL29557188 | 0.90 | KMT2A (0.68) | ECE1ALOX15LTA4HP2RY14ACE | |
| SCHEMBL1574598 | 0.90 | KMT2A (0.68) | ECE1ALOX15LTA4HP2RY14ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105198884-B | Pentacyclic indole quinolizine that the G1/G0 phases block, its synthesis, antitumor activity and application | 首都医科大学 | 2017-08-01 | — | — | CN | disclosed |
| CN-105198884-A | G1/G0-phase blocked pentacyclic indol-quinolizidine and compound, antineoplastic activity and application thereof | UNIV CAPITAL MEDICAL SCIENCES | 2015-12-30 | — | — | CN | disclosed |
| CN-101863926-A | Antitumor drug palladium coordination compound | UNIV HEBEI | 2010-10-20 | — | — | CN | disclosed |