Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 11/20 | 0.59 |
| ▸ | MTOR | P42345 | 9/20 | 0.57 |
| ▸ | PIK3R1 | P27986 | 4/20 | 0.56 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.56 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.56 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.56 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.56 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.56 |
| ▸ | PRKDC | P78527 | 1/20 | 0.56 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.56 |
| ▸ | PIK3R5 | Q8WYR1 | 1/20 | 0.56 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.56 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10328300 | 0.85 | PIK3CA (0.61) | PIK3CAMTORPIK3R1PIK3CBPIK3CD | |
| SCHEMBL1311057 | 0.85 | CRHBP (0.47) | PIK3CAMTORPIK3R1PIK3CBPIK3CD | |
| SCHEMBL28046969 | 0.82 | PIK3CA (0.54) | PIK3CAMTORPIK3R1PIK3CBPIK3CD | |
| SCHEMBL15334730 | 0.82 | PIK3CA (0.58) | PIK3CAMTORPIK3R1PIK3CBPIK3CD | |
| SCHEMBL28047097 | 0.82 | PIK3CA (0.71) | PIK3CAMTORPIK3R1PIK3CBPIK3CD | |
| SCHEMBL1309988 | 0.82 | CRHBP (0.51) | PIK3CAMTORPIK3R1MAP3K12KMT2A | |
| SCHEMBL16035197 | 0.81 | PIK3CA (0.59) | PIK3CAMTORPIK3R1PIK3CBPIK3CD | |
| SCHEMBL1311434 | 0.80 | PIK3CA (0.65) | PIK3CAMTORPIK3R1PIK3CBPIK3CD | |
| SCHEMBL19461018 | 0.80 | PIK3CA (0.68) | PIK3CAMTORPIK3R1PIK3CBPIK3CD | |
| SCHEMBL15946943 | 0.79 | PIK3CA (0.74) | PIK3CAMTORPIK3R1PIK3CBPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105541792-A | Polycyclic PI3K inhibitors | XUANZHU PHARMA CO LTD | 2016-05-04 | — | — | CN | disclosed |