Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 4/20 | 0.36 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 5/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 6/20 | 0.33 |
| ▸ | LMNA | P02545 | 7/20 | 0.33 |
| ▸ | THRB | P10828 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL280469 | 0.94 | SCN3A (0.39) | PTPN1SCN3ATP53MAPTLMNA | |
| SCHEMBL280290 | 0.88 | MAPT (0.39) | PTPN1SCN3ATP53MAPTLMNA | |
| SCHEMBL280307 | 0.83 | P2RX7 (0.40) | PTPN1TP53RXFP1MAPTLMNA | |
| SCHEMBL279488 | 0.81 | TP53 (0.40) | PTPN1TP53RXFP1MAPTLMNA | |
| SCHEMBL280031 | 0.80 | PTPN1 (0.40) | PTPN1TP53MAPTLMNATHRB | |
| SCHEMBL263837 | 0.79 | PTPN1 (0.35) | PTPN1SCN3ATP53RXFP1MAPT | |
| SCHEMBL13763088 | 0.79 | CYP1A2 (0.34) | PTPN1TP53MAPTLMNATHRB | |
| SCHEMBL279124 | 0.79 | LMNA (0.39) | PTPN1TP53RXFP1MAPTLMNA | |
| SCHEMBL10207171 | 0.78 | MAPT (0.49) | PTPN1TP53MAPTLMNATHRB | |
| SCHEMBL278857 | 0.77 | LMNA (0.48) | TP53MAPTLMNATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8134010-B2 | 4-[4-Methyl-5-(2-nitrooxy-ethyl)-thiazol-2-yl]-phenylamine; N-{4-[4-Methyl-5-(2-nitrooxy-ethyl)-thiazol-2-yl]-phenyl}-acetamide; or4-Methyl-5-(2-nitrooxy-ethyl)-2-(4-nitro-phenyl)-thiazole; cardiovascular, gastrointestinal, inflammatory, respiratory disease | RENOPHARM LTD. (IL) | 2012-03-13 | — | — | US | disclosed |
| US-7968575-B2 | Nitric oxide donors and uses thereof | RENOPHARM LTD. (IL) | 2011-06-28 | — | — | US | disclosed |
| US-7579477-B2 | Thiazole-based nitric oxide donors having alkyl substituent(s) and uses thereof | RENOPHARM LTD. (IL) | 2009-08-25 | — | — | US | disclosed |
| US-7498445-B2 | Thiazole-based nitric oxide donors capable of releasing two or more nitric oxide molecules and uses thereof | RENOPHARM LTD. (IL) | 2009-03-03 | — | — | US | disclosed |
| US-7368577-B2 | Thiazole-based nitric oxide donors having aryl substituent(s) and uses thereof | RENOPHARM LTD. (IL) | 2008-05-06 | — | — | US | disclosed |
| US-7332513-B2 | Thiazole-based nitric oxide donors having acyl substituent(s) and uses thereof | RENOPHARM LTD. (IL) | 2008-02-19 | — | — | US | disclosed |