Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Phenylacetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.77 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | CES2 | O00748 | 1/20 | 0.56 |
| ▸ | CES1 | P23141 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.52 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.52 |
| ▸ | PAM | P19021 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenylacetic Acid SCHEMBL30960397 | 1.00 | AKR1B1 (0.77) | AKR1B1LMNAABCC4GAATSHR | |
| Phenylacetic Acid SCHEMBL28218631 | 0.91 | AKR1B1 (0.94) | AKR1B1LMNAABCC4GAATSHR | |
| Phenylacetic Acid SCHEMBL28242469 | 0.88 | AKR1B1 (1.00) | AKR1B1LMNAABCC4GAATSHR | |
| Phenylacetic Acid SCHEMBL1459 | 0.88 | AKR1B1 (1.00) | AKR1B1LMNAABCC4GAATSHR | |
| Phenylacetic Acid SCHEMBL1330777 | 0.88 | AKR1B1 (1.00) | AKR1B1LMNAABCC4GAATSHR | |
| Phenylacetic Acid SCHEMBL9449909 | 0.88 | AKR1B1 (1.00) | AKR1B1LMNAABCC4GAATSHR | |
| Phenylacetic Acid SCHEMBL27758886 | 0.88 | AKR1B1 (1.00) | AKR1B1LMNAABCC4GAATSHR | |
| Phenylacetic Acid SCHEMBL13618842 | 0.88 | AKR1B1 (1.00) | AKR1B1LMNAABCC4GAATSHR | |
| Phenylacetic Acid SCHEMBL8843827 | 0.88 | AKR1B1 (0.65) | AKR1B1LMNAABCC4GAATSHR | |
| Phenylacetic Acid SCHEMBL8843836 | 0.88 | AKR1B1 (0.65) | AKR1B1LMNAABCC4GAATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105308669-B | Base board for display device and the display device using the base board for display device | 凸版印刷株式会社 | 2018-05-08 | — | — | CN | disclosed |
| CN-105339834-B | Liquid crystal display device having a plurality of pixel electrodes | 凸版印刷株式会社 | 2018-04-13 | — | — | CN | disclosed |
| CN-105339834-A | Liquid crystal display device having a plurality of pixel electrodes | TOPPAN PRINTING CO LTD | 2016-02-17 | — | — | CN | disclosed |
| CN-105308669-A | Substrate for display device, and display device using same | TOPPAN PRINTING CO LTD | 2016-02-03 | — | — | CN | disclosed |