Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR3 | O14843 | 3/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.35 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.35 |
| ▸ | GABRP | O00591 | 1/20 | 0.35 |
| ▸ | GABRD | O14764 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperazine SCHEMBL28214068 | 0.94 | FFAR3 (0.62) | FFAR3TDP1ALDH1A1HDAC3HDAC1 | |
| Piperazine SCHEMBL5818604 | 0.94 | FFAR3 (0.62) | FFAR3TDP1ALDH1A1HDAC3HDAC1 | |
| Propionic Acid SCHEMBL3790146 | 0.91 | — | — | |
| Piperidine SCHEMBL28047155 | 0.90 | FFAR3 (0.50) | FFAR3TDP1ALDH1A1LCKFYN | |
| Propionic Acid SCHEMBL29104606 | 0.88 | — | — | |
| Acetic Acid SCHEMBL2907405 | 0.85 | FFAR3 (0.54) | FFAR3LCKFYNGABRA5GABRB2 | |
| Acetic Acid SCHEMBL7118694 | 0.85 | FFAR3 (0.54) | FFAR3LCKFYNGABRA5GABRB2 | |
| Acetic Acid SCHEMBL9599616 | 0.85 | FFAR3 (0.54) | FFAR3LCKFYNGABRA5GABRB2 | |
| Acetic Acid SCHEMBL3451040 | 0.85 | FFAR3 (0.54) | FFAR3LCKFYNGABRA5GABRB2 | |
| Piperazine SCHEMBL7327328 | 0.85 | FFAR3 (0.54) | FFAR3LCKFYNGABRA5GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105338976-B | Antimicrobial polyamide composition and mastitis treatment | 梅里亚股份有限公司 | 2018-12-04 | — | — | CN | disclosed |
| CN-105338976-A | Antimicrobial polyamide composition and mastitis treatment | MERIAL INC | 2016-02-17 | — | — | CN | disclosed |