Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Piperidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR3 | O14843 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CHKA | P35790 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SLC6A1 | P30531 | 4/20 | 0.32 |
| ▸ | SLC6A11 | P48066 | 3/20 | 0.32 |
| ▸ | SLC6A13 | Q9NSD5 | 3/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.32 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.32 |
| ▸ | GABRP | O00591 | 1/20 | 0.32 |
| ▸ | GABRD | O14764 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyrrolidine SCHEMBL10413119 | 0.95 | FFAR3 (0.56) | FFAR3ALDH1A1TDP1CA2CHKA | |
| Pyrrolidine SCHEMBL28213560 | 0.95 | FFAR3 (0.56) | FFAR3ALDH1A1TDP1CA2CHKA | |
| Piperidine SCHEMBL6861563 | 0.95 | FFAR3 (0.56) | FFAR3ALDH1A1TDP1CA2CHKA | |
| Piperidine SCHEMBL1274941 | 0.95 | FFAR3 (0.56) | FFAR3ALDH1A1TDP1CA2CHKA | |
| Piperidine SCHEMBL4661791 | 0.90 | ALDH1A1 (0.45) | FFAR3ALDH1A1TDP1LCKFYN | |
| Piperazine SCHEMBL28047208 | 0.90 | FFAR3 (0.56) | FFAR3ALDH1A1TDP1LCKFYN | |
| Piperidine SCHEMBL192668 | 0.89 | ALDH1A1 (0.56) | FFAR3ALDH1A1LCKFYNCA2 | |
| Piperidine SCHEMBL29043025 | 0.89 | ALDH1A1 (0.56) | FFAR3ALDH1A1LCKFYNCA2 | |
| Piperidine SCHEMBL10332243 | 0.89 | ALDH1A1 (0.56) | FFAR3ALDH1A1LCKFYNCA2 | |
| Propionic Acid SCHEMBL9615008 | 0.87 | FFAR3 (0.59) | FFAR3ALDH1A1TDP1CA2CHKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105338976-B | Antimicrobial polyamide composition and mastitis treatment | 梅里亚股份有限公司 | 2018-12-04 | — | — | CN | disclosed |
| CN-105338976-A | Antimicrobial polyamide composition and mastitis treatment | MERIAL INC | 2016-02-17 | — | — | CN | disclosed |