SCHEMBL28047487

SCHEMBL28047487

COC(=O)c1cc(-c2cccc(F)c2)ccn1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.50
GRM5 P41594 1/20 0.48
KMO O15229 2/20 0.47
RPS6KB1 P23443 1/20 0.46
CSNK1D P48730 1/20 0.46
GSK3A P49840 1/20 0.46
GSK3B P49841 1/20 0.46
DYRK1A Q13627 1/20 0.46
NTRK2 Q16620 1/20 0.46
AURKB Q96GD4 1/20 0.46
TLR7 Q9NYK1 1/20 0.44
CYP4F2 P78329 1/20 0.44
CYP4A11 Q02928 1/20 0.44
TOP2A P11388 1/20 0.43
WNT3A P56704 1/20 0.43
MRGPRX4 Q96LA9 1/20 0.43
MEN1 O00255 2/20 0.43
KMT2A Q03164 2/20 0.43
MAPT P10636 2/20 0.43
LMNA P02545 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30800091 0.85 ALDH1A1 (0.54) ALDH1A1KMOMAPTLMNA
SCHEMBL2958040 0.84 SLC6A4 (0.46) ALDH1A1WNT3AMAPTLMNANPC1
SCHEMBL3712306 0.84 ALDH1A1 (0.51) ALDH1A1MAPTLMNA
SCHEMBL29735406 0.84 ALDH1A1 (0.51) ALDH1A1MAPTLMNA
SCHEMBL30945316 0.84 ALDH1A1 (0.50) ALDH1A1GRM5MAPTLMNA
SCHEMBL2305000 0.84 ALDH1A1 (0.50) ALDH1A1GRM5MAPTLMNA
SCHEMBL23201168 0.83 ALDH1A1 (0.51) ALDH1A1KMOWNT3AKMT2AMAPT
SCHEMBL13188268 0.83 EGFR (0.51) ALDH1A1KMOWNT3A
SCHEMBL1937391 0.82 CNR2 (0.59) ALDH1A1KMOTLR7MRGPRX4
SCHEMBL1938969 0.81 KMO (0.70) GRM5KMORPS6KB1CSNK1DGSK3A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105208859-A Novel 4-aminopyridine and 6-aminopyrimidine carboxylates as herbicides DOW AGROSCIENCES LLC 2015-12-30 CN disclosed