Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.62 |
| ▸ | GAA | P10253 | 6/20 | 0.62 |
| ▸ | HPGD | P15428 | 6/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.62 |
| ▸ | GLA | P06280 | 3/20 | 0.62 |
| ▸ | CASP1 | P29466 | 2/20 | 0.62 |
| ▸ | CASP7 | P55210 | 2/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | ATM | Q13315 | 1/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.60 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.54 |
| ▸ | MAPT | P10636 | 11/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | TP53 | P04637 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12719338 | 0.80 | ALDH1A1 (0.77) | ALDH1A1KDM4EGAAHPGDHSD17B10 | |
| SCHEMBL987836 | 0.76 | KDM4E (1.00) | ALDH1A1KDM4EGAAHPGDHSD17B10 | |
| SCHEMBL21257771 | 0.76 | ALDH1A1 (0.73) | ALDH1A1KDM4EGAAHPGDHSD17B10 | |
| SCHEMBL987936 | 0.75 | ALDH1A1 (1.00) | ALDH1A1KDM4EGAAHPGDHSD17B10 | |
| SCHEMBL31225635 | 0.74 | ALDH1A1 (0.72) | ALDH1A1KDM4EGAAHPGDHSD17B10 | |
| SCHEMBL11965099 | 0.74 | ALDH1A1 (0.60) | ALDH1A1KDM4EGAAHPGDHSD17B10 | |
| SCHEMBL20597096 | 0.74 | NOTUM (0.78) | ALDH1A1KDM4EGAAHPGDHSD17B10 | |
| SCHEMBL11271210 | 0.70 | ALDH1A1 (0.54) | ALDH1A1KDM4EGAAHPGDHSD17B10 | |
| SCHEMBL3809960 | 0.69 | ALDH1A1 (1.00) | ALDH1A1KDM4EGAAHPGDMAPT | |
| SCHEMBL29853545 | 0.69 | MAPT (0.71) | ALDH1A1KDM4EGAAHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102333779-B | Benzopyran and benzoxex PI3K inhibitor compounds and methods of use | GENENTECH, INC. (US) | 2015-12-09 | — | — | CN | disclosed |