Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.60 |
| ▸ | HPGD | P15428 | 8/20 | 0.60 |
| ▸ | GAA | P10253 | 7/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.60 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.60 |
| ▸ | GLA | P06280 | 3/20 | 0.58 |
| ▸ | CASP1 | P29466 | 3/20 | 0.58 |
| ▸ | CASP7 | P55210 | 3/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.53 |
| ▸ | MAPT | P10636 | 9/20 | 0.52 |
| ▸ | TP53 | P04637 | 4/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11965098 | 0.80 | KDM4E (0.65) | ALDH1A1HPGDGAAKDM4EHSD17B10 | |
| SCHEMBL11965100 | 0.77 | MAPT (0.46) | ALDH1A1HPGDGAAKDM4EHSD17B10 | |
| SCHEMBL12719338 | 0.77 | ALDH1A1 (0.77) | ALDH1A1HPGDGAAKDM4EHSD17B10 | |
| SCHEMBL20991197 | 0.77 | KDM4E (0.34) | ALDH1A1HPGDGAAKDM4EHSD17B10 | |
| SCHEMBL15274291 | 0.75 | MAOA (0.42) | ALDH1A1HPGDGAAKDM4EHSD17B10 | |
| SCHEMBL11965072 | 0.75 | KDM4E (0.56) | ALDH1A1HPGDGAAKDM4ENOTUM | |
| SCHEMBL987936 | 0.75 | ALDH1A1 (1.00) | ALDH1A1HPGDGAAKDM4EHSD17B10 | |
| SCHEMBL17339839 | 0.74 | NOTUM (0.36) | ALDH1A1HPGDGAAKDM4EHSD17B10 | |
| SCHEMBL20597096 | 0.74 | NOTUM (0.78) | ALDH1A1HPGDGAAKDM4EHSD17B10 | |
| SCHEMBL21257771 | 0.74 | ALDH1A1 (0.73) | ALDH1A1HPGDGAAKDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9624238-B2 | 4H-thieno[3,2-C]chromene-based inhibitors of Notum Pectinacetylesterase and methods of their use | LEXICON PHARMACEUTICALS, INC. (US) | 2017-04-18 | — | — | US | disclosed |
| US-20140256784-A1 | 4H-THIENO[3,2-C]CHROMENE-BASED INHIBITORS OF NOTUM PECTINACETYLESTERASE AND METHODS OF THEIR USE | OXFORD FINANCE LLC, AS COLLATERAL AGENT | 2014-09-11 | — | — | US | disclosed |
| US-20120302562-A1 | 4H-THIENO[3,2-C]CHROMENE-BASED INHIBITORS OF NOTUM PECTINACETYLESTERASE AND METHODS OF THEIR USE | LEXICON PHARMACEUTICALS, INC. | 2012-11-29 | — | — | US | disclosed |
| US-20120202794-A1 | COMPOUNDS | PHARMASSET, INC. (US) | 2012-08-09 | — | — | US | disclosed |
| US-20120202794-A1 | COMPOUNDS | PHARMASSET, INC. (US) | 2012-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120202794-A1 | COMPOUNDS | HAVCR2, MAVS, GOT2 | ALDH1A1 253/4885HPGD 2240/4885GAA 231/4885 |
| US-20140256784-A1 | 4H-THIENO[3,2-C]CHROMENE-BASED INHIBITORS OF NOTUM PECTINACETYLESTERASE AND METHODS OF THEIR USE | NOTUM, CES1, ACHE | ALDH1A1 1022/4885HPGD 521/4885GAA 94/4885 |
| US-20120302562-A1 | 4H-THIENO[3,2-C]CHROMENE-BASED INHIBITORS OF NOTUM PECTINACETYLESTERASE AND METHODS OF THEIR USE | NOTUM, CES1, ACHE | ALDH1A1 1022/4885HPGD 521/4885GAA 94/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.