Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.62 |
| ▸ | RAB9A | P51151 | 4/20 | 0.62 |
| ▸ | HPGD | P15428 | 4/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | PGR | P06401 | 2/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.54 |
| ▸ | AR | P10275 | 1/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27982705 | 0.84 | TP53 (0.62) | NPC1RAB9AKMT2AMEN1MAPT | |
| SCHEMBL31511907 | 0.83 | HSP90AB1 (0.65) | NPC1RAB9AHPGDCYP3A4ALDH1A1 | |
| SCHEMBL1831963 | 0.83 | HSP90AB1 (0.65) | NPC1RAB9AHPGDCYP3A4ALDH1A1 | |
| SCHEMBL5477586 | 0.83 | NPC1 (0.70) | NPC1RAB9AHPGDCYP3A4ALDH1A1 | |
| Hydrochloric Acid SCHEMBL28047706 | 0.83 | TP53 (0.61) | NPC1RAB9AKMT2AMEN1MAPT | |
| SCHEMBL4801464 | 0.82 | NPC1 (0.55) | NPC1RAB9AHPGDCYP3A4ALDH1A1 | |
| SCHEMBL6061493 | 0.82 | MCL1 (0.49) | HPGDALDH1A1MAPK1KMT2AMEN1 | |
| SCHEMBL3709147 | 0.81 | NPC1 (0.68) | NPC1RAB9AHPGDCYP3A4ALDH1A1 | |
| SCHEMBL38652178 | 0.81 | NPC1 (0.68) | NPC1RAB9AHPGDCYP3A4ALDH1A1 | |
| SCHEMBL2260356 | 0.81 | NPC1 (0.68) | NPC1RAB9AHPGDCYP3A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105189446-B | Phloroglucin analog derivative and its purposes in treating neurodegenerative disease | 中国医学科学院药物研究所 | 2018-07-20 | — | — | CN | disclosed |
| CN-105189446-A | Phloroglucinol derivatives and application thereof in treatment of neurodegenerative disorder | INST MATERIA MEDICA CAMS | 2015-12-23 | — | — | CN | disclosed |