Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 5/20 | 0.55 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | ACP1 | P24666 | 3/20 | 0.45 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.45 |
| ▸ | BACE1 | P56817 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | TOP2A | P11388 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28048692 | 0.87 | NCF1 (0.59) | NCF1SIGMAR1ACP1TOP2A | |
| SCHEMBL17433848 | 0.85 | NCF1 (0.57) | NCF1BACE1 | |
| SCHEMBL28825618 | 0.77 | TLR8 (0.56) | SLC6A3HRH3SIGMAR1BACE1 | |
| SCHEMBL17433976 | 0.75 | NCF1 (0.62) | NCF1BACE1 | |
| SCHEMBL6665713 | 0.74 | BACE1 (0.53) | NCF1BACE1 | |
| SCHEMBL6969427 | 0.74 | BACE1 (0.53) | NCF1BACE1 | |
| SCHEMBL28228172 | 0.74 | HRH3 (0.59) | SLC6A3HRH3HTR2A | |
| SCHEMBL4731923 | 0.72 | NCF1 (0.62) | NCF1 | |
| SCHEMBL17434077 | 0.72 | NCF1 (0.62) | NCF1SIGMAR1BACE1 | |
| SCHEMBL17433988 | 0.72 | TSHR (0.62) | NCF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105377851-A | BET bromodomain inhibitors and therapeutic methods using these inhibitors | UNIV MICHIGAN REGENTS | 2016-03-02 | — | — | CN | disclosed |