Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 12/20 | 0.43 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.38 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | RAF1 | P04049 | 1/20 | 0.34 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2521682 | 0.85 | KDM4E (0.48) | LCKTBK1KDM4EGAARAB9A | |
| SCHEMBL15573656 | 0.85 | LCK (0.41) | LCKCYP2C9CYP2C19NPSR1 | |
| SCHEMBL2524367 | 0.82 | KDM4E (0.48) | LCKKDM4EGAARAB9ACYP2C9 | |
| SCHEMBL2520688 | 0.81 | USP30 (0.40) | LCKKDM4EGAA | |
| SCHEMBL2520080 | 0.81 | KMT2A (0.45) | LCKKDM4ERAB9A | |
| SCHEMBL29019243 | 0.80 | LCK (0.39) | LCKBRD9 | |
| SCHEMBL27866744 | 0.80 | ALDH1A1 (0.46) | KDM4ERAB9A | |
| SCHEMBL19912149 | 0.80 | HDAC6 (0.37) | LCKKDM4ERAB9ANPSR1BRD9 | |
| SCHEMBL14800615 | 0.80 | PIM1 (0.37) | LCK | |
| SCHEMBL6523055 | 0.80 | LCK (0.47) | LCKGAARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102625807-B | 4-Substituted pyridin-3-yl-carboxamide compounds and methods of use | HOFFMAN-LA ROCHE LTD. (CH) | 2016-03-09 | — | — | CN | disclosed |