Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.53 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.50 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | IKBKB | O14920 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.46 |
| ▸ | F9 | P00740 | 1/20 | 0.45 |
| ▸ | F10 | P00742 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4851777 | 0.90 | HTR1A (0.51) | GRM5GRM2SLC6A4MAPK1HTT | |
| SCHEMBL28049625 | 0.90 | GRM5 (0.64) | GRM5GRM2SLC6A4MAPK1HTT | |
| SCHEMBL5176764 | 0.85 | MRGPRX4 (0.60) | MRGPRX4HTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL8881389 | 0.85 | HTT (0.62) | SLC6A4MAPK1HTTSMN1; SMN2MEN1 | |
| SCHEMBL28048524 | 0.82 | MAPK1 (0.64) | MAPK1HTTSMN1; SMN2IKBKBHTR1A | |
| SCHEMBL22517092 | 0.81 | MAPK1 (0.49) | GRM5GRM2SLC6A4MAPK1HTT | |
| SCHEMBL29726047 | 0.81 | MAPK1 (0.49) | GRM5GRM2SLC6A4MAPK1HTT | |
| SCHEMBL28011530 | 0.81 | MAPK1 (0.64) | GRM2MAPK1HTR1ADRD2GPR132 | |
| SCHEMBL2567241 | 0.81 | MAPK1 (0.50) | GRM5GRM2SLC6A4MAPK1HTT | |
| SCHEMBL28049586 | 0.81 | HTT (0.53) | MRGPRX4GRM2SLC6A4MAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105263490-A | Substituted triazolopyridines and methods of use | GENENTECH INC | 2016-01-20 | — | — | CN | disclosed |