Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 4/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21826552 | 0.88 | KEAP1 (0.47) | SLC6A3KMT2AMEN1ALDH1A1OPRM1 | |
| SCHEMBL27137776 | 0.87 | SLC6A2 (0.42) | SLC6A2SLC6A4SLC6A3SIGMAR1KMT2A | |
| SCHEMBL7067721 | 0.86 | MME (0.46) | OPRM1NPC1POLB | |
| Hydrochloric Acid SCHEMBL27151922 | 0.86 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3SIGMAR1KMT2A | |
| SCHEMBL28029681 | 0.85 | SLC6A2 (0.43) | SLC6A2SLC6A4SLC6A3OPRM1 | |
| SCHEMBL18440724 | 0.84 | KEAP1 (0.44) | SLC6A3KMT2AMEN1ALDH1A1CYP2C19 | |
| SCHEMBL20493250 | 0.83 | OPRM1 (0.43) | SLC6A2SLC6A4SLC6A3SIGMAR1KMT2A | |
| SCHEMBL17451241 | 0.83 | CYP2C19 (0.46) | SLC6A3KMT2AMEN1CYP2C19HSD11B1 | |
| SCHEMBL1919144 | 0.83 | SLC6A2 (0.56) | SLC6A2SLC6A4SLC6A3KMT2AMEN1 | |
| SCHEMBL1919601 | 0.81 | MEN1 (0.61) | KMT2AMEN1ALDH1A1OPRM1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105263490-B | Substituted triazolopyridines and methods of use | 基因泰克公司 | 2018-05-22 | — | — | CN | disclosed |
| CN-105263490-A | Substituted triazolopyridines and methods of use | GENENTECH INC | 2016-01-20 | — | — | CN | disclosed |