Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1
The experimentally established mechanism targets of Lactic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | SLC34A1 | Q06495 | 1/20 | 0.50 |
| ▸ | PGK1 | P00558 | 1/20 | 0.34 |
| ▸ | PGK2 | P07205 | 1/20 | 0.34 |
| ▸ | LAP3 | P28838 | 2/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | MMP8 | P22894 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lactic Acid SCHEMBL26913629 | 0.94 | TP53 (0.61) | TP53SLC34A1PGK1PGK2LAP3 | |
| Lactic Acid SCHEMBL28075168 | 0.89 | TP53 (0.61) | TP53SLC34A1PGK1PGK2LAP3 | |
| Lactic Acid SCHEMBL6117620 | 0.89 | TP53 (0.61) | TP53SLC34A1PGK1PGK2LAP3 | |
| Lactic Acid SCHEMBL3889551 | 0.89 | TP53 (0.61) | TP53SLC34A1PGK1PGK2LAP3 | |
| Lactic Acid SCHEMBL23525578 | 0.86 | TP53 (0.65) | TP53 | |
| Lactic Acid SCHEMBL5466565 | 0.86 | TP53 (0.65) | TP53 | |
| Lactic Acid SCHEMBL1840424 | 0.85 | TP53 (0.73) | TP53PGK1PGK2LAP3CA12 | |
| Lactic Acid SCHEMBL6273455 | 0.85 | TP53 (0.73) | TP53PGK1PGK2LAP3CA12 | |
| D-Lactic Acid SCHEMBL8220430 | 0.83 | TP53 (0.61) | TP53CA1 | |
| Phosphoric Acid SCHEMBL27518794 | 0.83 | SLC34A1 (0.50) | TP53SLC34A1LAP3CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105363017-A | Composition containing polymyxin B and preparation method thereof | BEIJING TIDE PHARMACEUTICAL CO LTD | 2016-03-02 | — | — | CN | disclosed |