Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1
The experimentally established mechanism targets of Lactic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | SLC34A1 | Q06495 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PGK1 | P00558 | 1/20 | 0.34 |
| ▸ | PGK2 | P07205 | 1/20 | 0.34 |
| ▸ | LAP3 | P28838 | 2/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | MMP8 | P22894 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lactic Acid SCHEMBL28049778 | 0.94 | TP53 (0.61) | TP53SLC34A1PGK1PGK2LAP3 | |
| Lactic Acid SCHEMBL3889551 | 0.94 | TP53 (0.61) | TP53SLC34A1LMNAPGK1PGK2 | |
| Lactic Acid SCHEMBL28075168 | 0.89 | TP53 (0.61) | TP53SLC34A1PGK1PGK2LAP3 | |
| Lactic Acid SCHEMBL6117620 | 0.89 | TP53 (0.61) | TP53SLC34A1PGK1PGK2LAP3 | |
| D-Lactic Acid SCHEMBL8220430 | 0.89 | TP53 (0.61) | TP53LMNACA1 | |
| Lactic Acid SCHEMBL23525578 | 0.86 | TP53 (0.65) | TP53LMNA | |
| Lactic Acid SCHEMBL5466565 | 0.86 | TP53 (0.65) | TP53LMNA | |
| Lactic Acid SCHEMBL6273455 | 0.85 | TP53 (0.73) | TP53PGK1PGK2LAP3CA12 | |
| Lactic Acid SCHEMBL1840424 | 0.85 | TP53 (0.73) | TP53PGK1PGK2LAP3CA12 | |
| L-Lactic Acid SCHEMBL27888974 | 0.83 | LMNA (0.43) | TP53SLC34A1LMNACA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230390285-A1 | Lurbinectedin Composition and Methods Making the Same | PHARMA MAR SA (ES) | 2023-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230390285-A1 | Lurbinectedin Composition and Methods Making the Same | TOP1, TOP2B, TOP2A | TP53 566/4885SLC34A1 1889/4885LMNA 98/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.