Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 16/20 | 0.70 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.52 |
| ▸ | CDC42BPA | Q5VT25 | 2/20 | 0.52 |
| ▸ | CDC42BPB | Q9Y5S2 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | JAK3 | P52333 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3565500 | 0.81 | LRRK2 (0.61) | LRRK2ROCK2ROCK1CDC42BPACDC42BPB | |
| SCHEMBL16178091 | 0.78 | LRRK2 (1.00) | LRRK2ROCK2ROCK1CDC42BPACDC42BPB | |
| SCHEMBL16178033 | 0.77 | LRRK2 (1.00) | LRRK2ROCK2ROCK1CDC42BPACDC42BPB | |
| SCHEMBL15805278 | 0.73 | SIK1 (0.68) | LRRK2GAAMAPTJAK2JAK3 | |
| SCHEMBL3574929 | 0.73 | LRRK2 (0.72) | LRRK2ROCK2ROCK1CDC42BPACDC42BPB | |
| SCHEMBL28049906 | 0.72 | LRRK2 (0.79) | LRRK2ROCK2ROCK1CDC42BPACDC42BPB | |
| SCHEMBL16178118 | 0.72 | LRRK2 (1.00) | LRRK2ROCK2ROCK1CDC42BPACDC42BPB | |
| SCHEMBL15805280 | 0.72 | LRRK2 (0.51) | LRRK2GAAMAPTJAK2JAK3 | |
| SCHEMBL5555757 | 0.71 | PGR (0.46) | GAAMAPT | |
| SCHEMBL16190651 | 0.71 | LRRK2 (0.67) | LRRK2ROCK2ROCK1CDC42BPACDC42BPB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105263930-A | Arylpyrrolopyridine derived compounds as lrrk2 inhibitors | LUNDBECK & CO AS H | 2016-01-20 | — | — | CN | claimed |
| CN-105263930-A | Arylpyrrolopyridine derived compounds as lrrk2 inhibitors | LUNDBECK & CO AS H | 2016-01-20 | — | — | CN | disclosed |