Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.62 |
| ▸ | MAPT | P10636 | 4/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | CES1 | P23141 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL135355 | 0.84 | L3MBTL1 (0.66) | L3MBTL1MAPTALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL25645639 | 0.82 | L3MBTL1 (0.64) | L3MBTL1MAPTALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL8675027 | 0.82 | L3MBTL1 (0.64) | L3MBTL1MAPTALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL10921663 | 0.81 | L3MBTL1 (0.62) | L3MBTL1MAPTALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL10921665 | 0.81 | L3MBTL1 (0.62) | L3MBTL1MAPTALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL11177908 | 0.81 | L3MBTL1 (0.62) | L3MBTL1MAPTALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL11011562 | 0.81 | L3MBTL1 (0.62) | L3MBTL1MAPTALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL28266215 | 0.80 | EPHX1 (0.53) | L3MBTL1MAPTALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL17992038 | 0.80 | ALDH1A1 (0.57) | L3MBTL1MAPTALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL16274031 | 0.80 | TSHR (0.59) | L3MBTL1MAPTALDH1A1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105263915-A | Glutamase inhibitors and method of use | AGIOS PHARMACEUTICALS INC | 2016-01-20 | — | — | CN | disclosed |