Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 19/20 | 0.79 |
| ▸ | IKBKB | O14920 | 1/20 | 0.48 |
| ▸ | CHUK | O15111 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16178131 | 0.88 | LRRK2 (1.00) | LRRK2 | |
| SCHEMBL28049873 | 0.82 | LRRK2 (0.72) | LRRK2IKBKBCHUK | |
| SCHEMBL3567725 | 0.81 | LRRK2 (1.00) | LRRK2IKBKBCHUK | |
| SCHEMBL16178118 | 0.81 | LRRK2 (1.00) | LRRK2 | |
| SCHEMBL16517761 | 0.81 | LRRK2 (0.73) | LRRK2 | |
| SCHEMBL16178091 | 0.81 | LRRK2 (1.00) | LRRK2 | |
| SCHEMBL16178033 | 0.79 | LRRK2 (1.00) | LRRK2 | |
| SCHEMBL28049907 | 0.76 | LRRK2 (0.77) | LRRK2 | |
| SCHEMBL28049906 | 0.75 | LRRK2 (0.79) | LRRK2 | |
| SCHEMBL3560182 | 0.73 | LRRK2 (0.69) | LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105263930-A | Arylpyrrolopyridine derived compounds as lrrk2 inhibitors | LUNDBECK & CO AS H | 2016-01-20 | — | — | CN | claimed |
| CN-105263930-A | Arylpyrrolopyridine derived compounds as lrrk2 inhibitors | LUNDBECK & CO AS H | 2016-01-20 | — | — | CN | disclosed |