Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 4/20 | 0.40 |
| ▸ | CA1 | P00915 | 4/20 | 0.40 |
| ▸ | CA9 | Q16790 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30640012 | 0.80 | ENPP1 (0.55) | FGFR1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8147583 | 0.80 | ENPP1 (0.55) | FGFR1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL27969057 | 0.79 | MAOA (0.47) | FGFR1HPGDMAOAALDH1A1GAA | |
| SCHEMBL1346309 | 0.78 | PDE4A (0.44) | FGFR1EGFRERBB2PDE4APDE4B | |
| SCHEMBL3424568 | 0.78 | PDE4A (0.44) | FGFR1EGFRPDE4APDE4BPDE4C | |
| SCHEMBL28049940 | 0.77 | ENPP1 (0.50) | FGFR1EGFRPDE4APDE4BPDE4C | |
| SCHEMBL28050040 | 0.76 | MAPT (0.45) | FGFR1EGFRPDE4APDE4BPDE4C | |
| SCHEMBL5044674 | 0.76 | PDE4A (0.42) | FGFR1EGFRPDE4APDE4BPDE4C | |
| SCHEMBL4512570 | 0.76 | KDR (0.57) | FGFR1EGFRPDE4APDE4BPDE4C | |
| SCHEMBL144584 | 0.76 | EGFR (0.54) | EGFRPDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105294578-A | Quinazoline derivative having targeted antitumor activity | GUANGDONG WHOLEWIN TECHNOLOGY CO LTD | 2016-02-03 | — | — | CN | disclosed |