Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | JAK1 | P23458 | 1/20 | 0.48 |
| ▸ | TYK2 | P29597 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.44 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2483079 | 0.81 | JAK2 (0.56) | JAK2JAK1TYK2ALDH1A1MRGPRX4 | |
| SCHEMBL27643680 | 0.77 | JAK2 (0.50) | JAK2JAK1TYK2ALDH1A1KMT2A | |
| SCHEMBL1198647 | 0.77 | PTPN1 (0.54) | JAK2JAK1TYK2ALDH1A1KMT2A | |
| SCHEMBL78221 | 0.76 | MRGPRX4 (0.61) | JAK2JAK1TYK2ALDH1A1KMT2A | |
| Hydrochloric Acid SCHEMBL15732642 | 0.76 | JAK2 (0.49) | JAK2JAK1TYK2ALDH1A1KMT2A | |
| Hydrochloric Acid SCHEMBL18861026 | 0.75 | MRGPRX4 (0.59) | JAK2JAK1TYK2ALDH1A1KMT2A | |
| SCHEMBL10658142 | 0.74 | JAK2 (0.56) | JAK2JAK1TYK2ALDH1A1KMT2A | |
| SCHEMBL24073216 | 0.74 | ALDH1A1 (0.62) | JAK2JAK1TYK2ALDH1A1KMT2A | |
| SCHEMBL29405924 | 0.74 | JAK2 (0.47) | JAK2JAK1TYK2ALDH1A1KMT2A | |
| SCHEMBL13730810 | 0.74 | JAK2 (0.47) | JAK2JAK1TYK2ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102317278-B | 4-azetidinyl-1-heteroaryl-hexalin the antagonist of CCR2 | JANSSEN PHARMACEUTICA N.V. (BE) | 2016-01-06 | — | — | CN | disclosed |