Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | APAF1 | O14727 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.42 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8636888 | 0.87 | NPSR1 (0.53) | NPC1APAF1NPSR1TSHRKMT2A | |
| SCHEMBL16100783 | 0.87 | SIRT2 (0.45) | TSHRKMT2AMEN1PTPN1BCAT2 | |
| SCHEMBL30610439 | 0.86 | NPSR1 (0.47) | NPC1APAF1NPSR1TSHRKMT2A | |
| SCHEMBL3644388 | 0.86 | NPSR1 (0.47) | NPC1NPSR1TSHRKMT2APTPN1 | |
| SCHEMBL8034169 | 0.86 | PTPN1 (0.50) | NPC1APAF1NPSR1TSHRKMT2A | |
| SCHEMBL27617215 | 0.81 | AKR1C3 (0.47) | NPC1APAF1NPSR1TSHRKMT2A | |
| SCHEMBL27617112 | 0.80 | NPSR1 (0.41) | NPC1APAF1NPSR1TSHRKMT2A | |
| SCHEMBL28609649 | 0.80 | GAA (0.46) | NPC1APAF1NPSR1TSHRKMT2A | |
| SCHEMBL8636684 | 0.80 | KDM4E (0.43) | NPC1TSHRKMT2AMEN1PTPN1 | |
| SCHEMBL2762268 | 0.79 | MAPT (0.46) | NPC1NPSR1TSHRBCAT2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105408326-A | Novel process for the preparation of spiroheterocyclic pyrrolidine diones | SYNGENTA PARTICIPATIONS AG | 2016-03-16 | — | — | CN | disclosed |