Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.51 |
| ▸ | TACR1 | P25103 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.44 |
| ▸ | GSK3A | P49840 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.44 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.44 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
| ▸ | TDP2 | O95551 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17151139 | 0.89 | LRRK2 (0.50) | LRRK2TACR1TTKACLY | |
| SCHEMBL15650470 | 0.86 | ALDH1A1 (0.56) | LRRK2TACR1KDM4EALDH1A1MAPT | |
| SCHEMBL22000128 | 0.86 | TUBB4A (0.54) | LRRK2TACR1KMT2AMEN1GSK3B | |
| SCHEMBL17148214 | 0.83 | TTK (0.47) | LRRK2TACR1KDM4EALDH1A1MAPT | |
| SCHEMBL19841829 | 0.83 | LRRK2 (0.47) | LRRK2TACR1KDM4EALDH1A1MAPT | |
| SCHEMBL23033356 | 0.83 | LRRK2 (0.55) | LRRK2TACR1KMT2AMEN1HSD17B10 | |
| SCHEMBL5814966 | 0.82 | TACR1 (0.49) | LRRK2TACR1KDM4EALDH1A1KMT2A | |
| SCHEMBL6600060 | 0.82 | CCNB2 (0.47) | KDM4EALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL17049267 | 0.79 | LRRK2 (0.53) | LRRK2TACR1KDM4EALDH1A1MAPT | |
| SCHEMBL14675684 | 0.77 | CLK4 (0.48) | KDM4EALDH1A1MAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105229009-B | 2-phenylimidazo [1,2-A ] pyrimidines as imaging agents | 豪夫迈·罗氏有限公司 | 2017-09-29 | — | — | CN | claimed |
| CN-105229009-A | 2-phenylimidazo [1,2-A ] pyrimidines as imaging agents | HOFFMANN LA ROCHE | 2016-01-06 | — | — | CN | claimed |
| CN-105229009-B | 2-phenylimidazo [1,2-A ] pyrimidines as imaging agents | 豪夫迈·罗氏有限公司 | 2017-09-29 | — | — | CN | disclosed |
| CN-105229009-A | 2-phenylimidazo [1,2-A ] pyrimidines as imaging agents | HOFFMANN LA ROCHE | 2016-01-06 | — | — | CN | disclosed |