SCHEMBL28050809

SCHEMBL28050809

O=P(O)(O)c1ccccc1O.c1ccc(-c2cccc(-c3ccccc3)c2)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC8 Q9BY41 2/20 0.53
HDAC4 P56524 1/20 0.53
HDAC2 Q92769 1/20 0.53
GGPS1 O95749 3/20 0.49
ACMSD Q8TDX5 3/20 0.47
PTPN1 P18031 1/20 0.46
PTPN5 P54829 1/20 0.46
CYP1A2 P05177 1/20 0.45
CYP3A4 P08684 1/20 0.45
CYP2C9 P11712 1/20 0.45
CYP2C19 P33261 1/20 0.45
KDM4E B2RXH2 1/20 0.45
POLB P06746 1/20 0.45
KMO O15229 1/20 0.44
ALOX5 P09917 1/20 0.44
CA2 P00918 1/20 0.44
FDPS P14324 1/20 0.44
MMP8 P22894 1/20 0.44
MMP14 P50281 1/20 0.44
CA9 Q16790 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Biphenyl SCHEMBL28050797 0.92 CYP1A2 (0.50) HDAC8HDAC4HDAC2PTPN5CYP1A2
SCHEMBL1227487 0.84 CYP3A4 (0.52) CYP1A2CYP3A4CYP2C9CYP2C19KDM4E
Potassium SCHEMBL11350259 0.82 CYP3A4 (0.50) CYP1A2CYP3A4CYP2C9CYP2C19KDM4E
SCHEMBL11350253 0.82 CYP3A4 (0.50) CYP1A2CYP3A4CYP2C9CYP2C19KDM4E
SCHEMBL28825834 0.80 RXRB (0.48) HDAC8HDAC4HDAC2PTPN1PTPN5
SCHEMBL28050892 0.80 GGPS1 (0.47) HDAC8HDAC4HDAC2GGPS1ACMSD
Biphenyl SCHEMBL27925618 0.78 KDM4E (0.49) HDAC8HDAC4HDAC2ACMSDKDM4E
Ethylenediamine SCHEMBL10783198 0.75 CYP3A4 (0.49) CYP1A2CYP3A4CYP2C9CYP2C19KDM4E
Biphenyl SCHEMBL27984932 0.73 CYP1A2 (0.51) HDAC8HDAC4HDAC2CYP1A2CYP3A4
SCHEMBL7188804 0.72 CA2 (0.62) HDAC8HDAC4HDAC2GGPS1PTPN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105175596-A Method for catalyzing copolymerization of ethylene and norbornene UNIV TIANJIN 2015-12-23 CN disclosed