Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.55 |
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | RXRA | P19793 | 2/20 | 0.50 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.50 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | PTGER1 | P34995 | 3/20 | 0.49 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30362096 | 1.00 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4DMRGPRX4 | |
| SCHEMBL28034346 | 0.89 | PDE4B (0.53) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL2803310 | 0.88 | PDE4B (0.55) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL29556736 | 0.87 | MRGPRX4 (0.62) | MRGPRX4NPC1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL1600077 | 0.87 | MRGPRX4 (0.62) | MRGPRX4NPC1HPGDRAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL10857748 | 0.86 | MRGPRX4 (0.61) | MRGPRX4NPC1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL28034335 | 0.82 | TSHR (0.64) | PDE4APDE4BPDE4CPDE4DMRGPRX4 | |
| SCHEMBL29670247 | 0.81 | TSHR (0.66) | PDE4APDE4BPDE4CPDE4DMRGPRX4 | |
| SCHEMBL1031663 | 0.81 | CA12 (0.63) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL30575456 | 0.81 | CA12 (0.63) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110698459-B | 1-phenyl-2-pyridylalkyl alcohol derivatives as phosphodiesterase inhibitors | 奇斯药制品公司 | 2023-05-05 | — | — | CN | disclosed |
| CN-110698459-A | 1-phenyl-2-pyridylalkyl alcohol derivatives as phosphodiesterase inhibitors | 奇斯药制品公司 | 2020-01-17 | — | — | CN | disclosed |
| US-9944612-B2 | 1-phenyl-2-pyridinyl alkyl alcohol derivatives as phosphodiesterase inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2018-04-17 | — | — | US | disclosed |
| US-9944612-B2 | 1-phenyl-2-pyridinyl alkyl alcohol derivatives as phosphodiesterase inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2018-04-17 | — | — | US | disclosed |
| EP-2928869-A1 | 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | Chiesi Farmaceutici S.p.A. (IT) | 2015-10-14 | — | — | EP | disclosed |
| CN-104822659-A | 1-Phenyl-2-pyridylalkyl alcohol derivatives as phosphodiesterase inhibitors | CHIESI FARMA SPA | 2015-08-05 | — | — | CN | disclosed |
| WO-2014086865-A1 | 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2014-06-12 | — | — | WO | disclosed |
| WO-2014086865-A1 | 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2014-06-12 | — | — | WO | disclosed |
| US-20140155391-A1 | 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2014-06-05 | — | — | US | disclosed |
| US-20140155391-A1 | 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2014-06-05 | — | — | US | disclosed |
| US-20140155391-A1 | 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2014-06-05 | — | — | US | disclosed |
| WO-2010132016-A1 | BIS-(SULFONYLAMINO) DERIVATIVES FOR TREATMENT OF PAIN AND INFLAMMATION | ASTRAZENECA AB (SE) | 2010-11-18 | — | — | WO | disclosed |
| WO-2010132016-A1 | BIS-(SULFONYLAMINO) DERIVATIVES FOR TREATMENT OF PAIN AND INFLAMMATION | ASTRAZENECA AB (SE) | 2010-11-18 | — | — | WO | disclosed |
| US-20100292279-A1 | Bis-(Sulfonylamino) Derivatives in Therapy | ASTRAZENECA AB (SE) | 2010-11-18 | — | — | US | disclosed |
| US-20100292279-A1 | Bis-(Sulfonylamino) Derivatives in Therapy | ASTRAZENECA AB (SE) | 2010-11-18 | — | — | US | disclosed |
| US-20100292279-A1 | Bis-(Sulfonylamino) Derivatives in Therapy | ASTRAZENECA AB (SE) | 2010-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140155391-A1 | 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | PDE4A, PDE4B, PDE3A | PDE4A 1/4885PDE4B 2/4885PDE4C 8/4885 |
| US-20100292279-A1 | Bis-(Sulfonylamino) Derivatives in Therapy | PTGER1, SULT2A1, SULT1E1 | PDE4A 1098/4885PDE4B 1521/4885PDE4C 2223/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.