Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | CCNC | P24863 | 2/20 | 0.39 |
| ▸ | CDK8 | P49336 | 2/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22886304 | 0.81 | CYP2A6 (0.55) | DYRK1AUHRF1MAPK14MAPK1 | |
| SCHEMBL14571424 | 0.79 | KDM4E (0.56) | KDM4EALDH1A1HPGDGLAGAA | |
| SCHEMBL23278779 | 0.79 | DYRK1A (0.42) | DYRK1AUHRF1MAPK14CCNCCDK8 | |
| SCHEMBL28829364 | 0.76 | MAP4K4 (0.44) | KDM4EMAPTDYRK1AUHRF1MAPK14 | |
| SCHEMBL14571433 | 0.76 | KDM4E (0.56) | KDM4EALDH1A1HPGDGLAGAA | |
| SCHEMBL6843188 | 0.76 | ALDH1A1 (0.66) | KDM4EALDH1A1HPGDGLAGAA | |
| SCHEMBL17505983 | 0.75 | KDM4E (0.59) | KDM4EALDH1A1HPGDGLAGAA | |
| SCHEMBL17143839 | 0.73 | JAK3 (0.42) | DYRK1AJAK3MAPK14PIK3CBPDK2 | |
| SCHEMBL687180 | 0.73 | KDM4E (0.55) | KDM4EALDH1A1HPGDGLAGAA | |
| SCHEMBL30308690 | 0.73 | DYRK1A (0.65) | DYRK1AUHRF1CCNCCDK8PIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105209449-A | Inhibitors of the kynurenine pathway | CURADEV PHARMA PRIVATE LTD | 2015-12-30 | — | — | CN | disclosed |