Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.63 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.63 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.63 |
| ▸ | TAAR1 | Q96RJ0 | 8/20 | 0.54 |
| ▸ | HTR1A | P08908 | 1/20 | 0.54 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | AHR | P35869 | 2/20 | 0.41 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.40 |
| ▸ | DAO | P14920 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | KRAS | P01116 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9217335 | 0.81 | GPR84 (0.62) | ADRA2AADRA2BADRA2CTAAR1HTR1A | |
| SCHEMBL2366649 | 0.79 | ADRA2A (0.97) | ADRA2AADRA2BADRA2CTAAR1HTR1A | |
| SCHEMBL28103549 | 0.79 | ADRA2A (0.69) | ADRA2AADRA2BADRA2CTAAR1HTR1A | |
| SCHEMBL8946914 | 0.76 | ADRA2A (0.61) | ADRA2AADRA2BADRA2CTAAR1HTR1A | |
| SCHEMBL8051573 | 0.75 | ADRA2A (0.59) | ADRA2AADRA2BADRA2CTAAR1HTR1A | |
| SCHEMBL955969 | 0.74 | ADRA2A (0.67) | ADRA2AADRA2BADRA2CTAAR1HTR1A | |
| Hydrochloric Acid SCHEMBL29751822 | 0.73 | ADRA2A (0.62) | ADRA2AADRA2BADRA2CTAAR1HTR1A | |
| SCHEMBL8051283 | 0.73 | AHR (0.50) | PIK3CDAHRDAOBCHEMEN1 | |
| SCHEMBL7330556 | 0.73 | MEN1 (0.62) | AHRDAOMEN1CYP3A4MAPT | |
| SCHEMBL955122 | 0.72 | TAAR1 (0.68) | ADRA2AADRA2BADRA2CTAAR1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105229003-A | 2- (1H-indol-4-ylmethyl) -3H-imidazo [4,5-B ] pyridine-6-carbonitrile derivatives as complement factor B inhibitors for the treatment of ophthalmic diseases | NOVARTIS AG | 2016-01-06 | — | — | CN | disclosed |
| CN-105229003-A | 2- (1H-indol-4-ylmethyl) -3H-imidazo [4,5-B ] pyridine-6-carbonitrile derivatives as complement factor B inhibitors for the treatment of ophthalmic diseases | NOVARTIS AG | 2016-01-06 | — | — | CN | disclosed |