Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | SIRT2 | Q8IXJ6 | 7/20 | 0.50 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.50 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL175535 | 0.82 | KDM4E (0.56) | KDM4EALDH1A1HPGDSIRT2SIRT1 | |
| SCHEMBL9921482 | 0.82 | KDM4E (0.56) | KDM4EALDH1A1HPGDSIRT2SIRT1 | |
| SCHEMBL10424663 | 0.82 | SIRT2 (0.62) | KDM4EALDH1A1HPGDSIRT2SIRT1 | |
| SCHEMBL30268242 | 0.80 | FABP4 (0.57) | KDM4EALDH1A1HPGDPOLBHSD17B10 | |
| SCHEMBL3378250 | 0.80 | FABP4 (0.57) | KDM4EALDH1A1HPGDPOLBHSD17B10 | |
| SCHEMBL5365142 | 0.80 | KDM4E (0.65) | KDM4EALDH1A1HPGDSIRT2MAPT | |
| SCHEMBL213832 | 0.80 | KDM4E (0.55) | KDM4EALDH1A1HPGDSIRT2SIRT1 | |
| SCHEMBL2685883 | 0.78 | KDM4E (0.53) | KDM4EALDH1A1HPGDSIRT2SIRT1 | |
| SCHEMBL687902 | 0.78 | KDM4E (0.53) | KDM4EALDH1A1HPGDSIRT2SIRT1 | |
| SCHEMBL704708 | 0.78 | KDM4E (0.62) | KDM4EALDH1A1HPGDSIRT2SIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102971305-B | Heterocyclic antiviral compounds | F. HOFFMANN-LA ROCHE AG (CH) | 2016-02-03 | — | — | CN | disclosed |